Neuroblastoma (NB) is a pediatric cancer of the sympathetic nervous system and one of the
most common solid tumors in infancy. Amplification of MYCN, copy number alterations, …

Oncogene amplification on extrachromosomal DNA (ecDNA) is a common event, driving
aggressive tumor growth, drug resistance and shorter survival. Currently, the impact of …

… We show that tumor DNA in the blood of patients with EwS is highly and characteristically
fragmented, we identify an EwS-specific epigenetic signature among regional fragmentation …

Pediatric cancers often mimic fetal tissues and express proteins normally silenced postnatally
that could serve as immune targets. We developed T cells expressing chimeric antigen …

Zebrafish xenotransplantation models are increasingly applied for phenotypic drug screening
to identify small compounds for precision oncology. Larval zebrafish xenografts offer the …

Metastasis is the major cause of cancer-related deaths. Neuroblastoma (NB), a childhood
tumor has been molecularly defined at the primary cancer site, however, the bone marrow (BM…

Cell motility is a crucial biological process that plays a critical role in the development of
multicellular organisms and is essential for tissue formation and regeneration. However, …

Telomere maintenance by telomerase activation or alternative lengthening of telomeres (ALT)
is a major determinant of poor outcome in neuroblastoma. Here, we screen for ALT in …

… (Allan Hanbury and Sabine Taschner-Mandl contributed equally to this work.) (Corresponding
authors: Allan Hanbury; Sabine Taschner-Mandl.) Florian Kromp, Eva Bozsaky, Inge M. …

… Taschner-Mandl and M. Ambros prepared samples for the dataset. W. … Weiss and S.
Taschner-Mandl acquired all images of the annotated dataset. F. Kromp, T. …