Current methods for assaying angiogenesis in vitro and in vivo

CA Staton, SM Stribbling, S Tazzyman… - International journal …, 2004 - Wiley Online Library
… Endothelial cells move, via a process called chemotaxis, along a gradient of
angiogenesis-inducing factor(s) such as VEGF. Modified Boyden chamber assays have been used to …

Neutrophils: key mediators of tumour angiogenesis

S Tazzyman, CE Lewis… - International journal of …, 2009 - Wiley Online Library
… into mice bearing A549 xenograft tumours, the antagonist inhibited neutrophil recruitment
into these tumours, which resulted in a significant reduction in tumour growth (Tazzyman, Barry…

Neutrophil-mediated tumour angiogenesis: subversion of immune responses to promote tumour growth

S Tazzyman, H Niaz, C Murdoch - Seminars in cancer biology, 2013 - Elsevier
Neutrophils are rapidly responding, phagocytes that are an essential part of the host innate
immune response to invading micro-organisms. Along with other leucocytes they also play a …

Perivascular M2 macrophages stimulate tumor relapse after chemotherapy

…, I Keklikoglou, OC Olson, S Tazzyman, S Danson… - Cancer research, 2015 - AACR
Tumor relapse after chemotherapy-induced regression is a major clinical problem, because
it often involves inoperable metastatic disease. Tumor-associated macrophages (TAM) are …

Expression of Tie-2 by human monocytes and their responses to angiopoietin-2

C Murdoch, S Tazzyman, S Webster… - The Journal of …, 2007 - journals.aai.org
… The thermal profile for PCR was 15 s at 95C, 15 s at 55C, 30 s at 68C. Thirty-five amplification
cycles were used for both Tie-2 and β-actin, which was used as an endogenous control. …

Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models

…, E Güç, ML Squadrito, LM Spring, S Tazzyman… - Nature cell …, 2019 - nature.com
… The statistical analyses were performed using unpaired two-tailed Student’s t-tests (d,g)
or one-way ANOVA with Tukey’s multiple comparison tests (e,f). The data in g show three …

Bacterial delivery of a novel cytolysin to hypoxic areas of solid tumors

RM Ryan, J Green, PJ Williams, S Tazzyman, S Hunt… - Gene therapy, 2009 - nature.com
… Furthermore, S. typhimurium accumulates in tumors as small … Even though this attenuated
strain of S. typhimurium has an … We overcame this issue by coupling S. typhimurium with a …

Plasticity in tumor-promoting inflammation: impairment of macrophage recruitment evokes a compensatory neutrophil response

JC Pahler, S Tazzyman, N Erez, YY Chen, C Murdoch… - Neoplasia, 2008 - Elsevier
… In vitro bioassays revealed that macrophages produce soluble factor(s) that can suppress
neutrophil dynamics, as evidenced by reduced chemotaxis in response to CXCL8, and …

Five degrees of happiness: Effective smiley face likert scales for evaluating with children

L Hall, C Hume, S Tazzyman - Proceedings of the the 15th international …, 2016 - dl.acm.org
… MIXER provides the evaluand for the studies reported in this paper with eCute’s evaluation
approach involving multiple formative evaluations feeding into the design of MIXER …

Fibrin fragment E stimulates the proliferation, migration and differentiation of human microvascular endothelial cells in vitro

CA Bootle-Wilbraham, S Tazzyman, WD Thompson… - Angiogenesis, 2001 - Springer
Various factors involved in haemostasis also regulate the development of new blood vessels
by a process called angiogenesis. Enzymatic cleavage of fibrin yields a variety of fibrin …