While the link between obesity and type 2 diabetes is clear on an epidemiological level, the
underlying mechanism linking these two common disorders is not as clearly understood. …

… the capacity of the body’s AT storage rate to deal with acute … We will now discuss the impact
on the liver of the body’s long… lipotoxicity hypotheses are reviewed by Virtue and Vidal-Puig…

In this review we discuss practical considerations for the assessment of brown adipose tissue
in rodent models, focusing on mice. The central aim of the review is to provide a critical …

Thermogenesis in brown adipose tissue (BAT) is fundamental to energy balance and is also
relevant for humans. Bone morphogenetic proteins (BMPs) regulate adipogenesis, and, …

… The sample was homogenized, vortexed (2 min for liver or 15 s for islets), let to stand (1 h
for liver, 20 min for islets), and centrifuged at 10,000 RPM for 3 min. From the separated lower …

… Our discoveries relating to metformin’s effects via GDF15 … mechanism through which
metformin’s action on the intestinal … adjustment by Tukey’s or Sidak’s test. Metabolic rate was …

… p < 0.001 by two-tailed Student’s t test. Note all fasted leptin values were under the …
The analytic processes of b-Hydroxybutyrate were conducted according to the manufacturer’s …

Mechanisms underlying obesity-related metabolic disorders are poorly understood. Samuel
Virtue and Antonio Vidal-Puig explore the evidence for an emerging hypothesis that …

Identification of early mechanisms that may lead from obesity towards complications such as
metabolic syndrome is of great interest. Here we performed lipidomic analyses of adipose …

OBJECTIVE—Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2) is a recessive disorder
featuring near complete absence of adipose tissue. Remarkably, although the causative …