… By screening sequences against probable sources of preserved leathers, the research
team showed that the iceman’s hat came from Brown Bear, his quiver from Roe deer and his …

Transcriptional control in large genomes often requires looping interactions between distal
DNA elements, such as enhancers and target promoters. Current chromosome conformation …

Long-range interactions between regulatory elements and gene promoters play key roles in
transcriptional regulation. The vast majority of interactions are uncharted, constituting a …

… We created sub-pools of G1, early-S and late-S–G2 cells in silico to compare insulation
patterns between the three major cell-cycle phases. We found that the locations of TAD borders …

… While we agree that this is a possible interpretation of that scenario, it should be noted that
the trans/cis ratio depends on the genome’s size and the number of chromosomes that each …

… from preferential PCR amplification rather than independent ligation events (SW Wingett, S
Schoenfelder, M Furlan-Magaril, T Nagano, P Fraser, S Andrews, in prep.). Compared to our …

The Polycomb repressive complexes PRC1 and PRC2 maintain embryonic stem cell (ESC)
pluripotency by silencing lineage-specifying developmental regulator genes 1 . Emerging …

… In Additional file 2: Figure S4 we show evidence that CHiCAGO’s parameter estimation
procedures are robust in the presence of undersampling; the implications of undersampling in …

Cellular senescence has been implicated in tumor suppression, development, and aging
and is accompanied by large-scale chromatin rearrangements, forming senescence-…

… of trans ligations represent random events we calculated the total number of trans ligations
(N T ) made by each of the 1077 captured HindIII fragments as a measure of the fragment’s “…