Deficits in cognition are a core feature of many psychiatric conditions, including schizophrenia,
where the severity of such deficits is a strong predictor of long-term outcome. Impairment …

The mediodorsal thalamus (MD) shares reciprocal connectivity with the prefrontal cortex (PFC),
and decreased MD–PFC connectivity is observed in schizophrenia patients. Patients …

The ventral hippocampus (vHPC), medial prefrontal cortex (mPFC), and basolateral amygdala
(BLA) are each required for the expression of anxiety-like behavior. Yet the role of each …

Cognitive deficits are central to schizophrenia, but the underlying mechanisms still remain
unclear. Imaging studies performed in patients point to decreased activity in the mediodorsal …

Historically, preclinical stress studies have often omitted female subjects, despite evidence
that women have higher rates of anxiety and depression. In rodents, many stress …

Decreased hippocampal-prefrontal synchrony may mediate cognitive deficits in schizophrenia,
but it remains unclear which cells orchestrate this long-range synchrony. Parvalbumin (PV…

Background Cognitive inflexibility is a core symptom of several mental disorders including
schizophrenia. Brain imaging studies in schizophrenia patients performing cognitive tasks …

A classic view of the striatum holds that activity in direct and indirect pathways oppositely
modulates motor output. Whether this involves direct control of movement, or reflects a …

Schizophrenia is a heterogeneous and poorly understood mental disorder that is presently
defined solely by its behavioral symptoms. Advances in genetic, epidemiological and brain …

Cholinergic interneurons (ChINs) in the nucleus accumbens (NAc) have been implicated in
the extinction of drug associations, as well as related plasticity in medium spiny neurons (…