ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of the …

Infrared spectroscopic imaging is widely used for the visualization of biomolecule structures,
and techniques such as optical photothermal infrared (OPTIR) microspectroscopy can …

Label-free chemical imaging of living and functioning systems is the holy grail of biochemical
research. However, existing techniques often require extensive sample preparation to …

Apolipoprotein E (APOE), one of the primary lipoproteins in the brain has three isoforms in
humans, APOE2, APOE3, and APOE4. APOE4 is the most well-established risk factor …

Alzheimer’s disease (AD) is increasingly seen as a disease of synapses and diverse
evidence has implicated the amyloid-β peptide (Aβ) in synapse damage. The molecular and …

Synaptic changes and neuronal network dysfunction are among the earliest changes in
Alzheimer’s disease (AD). Apolipoprotein E4 (ApoE4), the major genetic risk factor in AD, has …

Apolipoprotein E4 (ApoE4) is the most important genetic risk factor for Alzheimer’s disease (AD).
Among the earliest changes in AD is endosomal enlargement in neurons, which was …

The proper function of the nervous system is dependent on the appropriate timing of neuronal
firing. Synapses continually undergo rapid activity-dependent modifications that require …

… Sc., and Paul F. Schmidt are with the Agis Health Insurance Company, Amersfoort, The
Netherlands. Piet JA Stam is also with the Institute for Health Policy and Management, Erasmus …

Background APOE genotype is known as the most important genetic risk factor for developing
AD. Understanding the cellular differences between the ApoE isoforms will be crucial for …