The concept that chemokines, cytokines and pro-inflammatory mediators act in a co-ordinated
fashion to drive the initiation of the inflammatory reaction is well understood. The …

Accumulation of lactate in the tissue microenvironment is a feature of both inflammatory
disease and cancer. Here, we assess the response of immune cells to lactate in the context of …

… Headland and colleagues found MVs present in the synovial fluid of patients with
rheumatoid arthritis—an autoimmune disease that degrades cartilage in the joints. Cartilage is …

Interest in extracellular vesicle biology has exploded in the past decade, since these
microstructures seem endowed with multiple roles, from blood coagulation to inter-cellular …

Rheumatoid arthritis (RA) is a debilitating disease characterized by persistent accumulation
of leukocytes within the articular cavity and synovial tissue. Metabololipidomic profiling of …

… It remains unclear whether dysbiosis per se contributes to increased cellular activation;
however, these observations have led to the hypothesis that bacteria contribute to disease …

Neutrophil activation and adhesion must be tightly controlled to prevent complications
associated with excessive inflammatory responses. The role of the anti‐inflammatory peptide …

Argonaute (AGO) proteins execute microRNA (miRNA)-mediated gene silencing. However,
it is unclear whether all 4 mammalian AGO proteins (AGO1, AGO2, AGO3, and AGO4) are …

We hypothesized that exudates collected at the beginning of the resolution phase of
inflammation might be enriched for tissue protective molecules; thus an integrated cellular and …

The authors recently became aware that representative illustrations presented in Figure 2A
might be mistaken for original data. As this panel was used strictly for demonstrative purposes…