User profiles for SG McInally

Shane Gregory McInally

Worcester Polytechnic Institute
Verified email at wpi.edu
Cited by 343

Microtubule organelles in Giardia

KD Hagen, SG McInally, ND Hilton, SC Dawson - Advances in parasitology, 2020 - Elsevier
Giardia lamblia is a widespread parasitic protist with a complex MT cytoskeleton that is critical
for motility, attachment, mitosis and cell division, and transitions between its two life cycle …

Robust and stable transcriptional repression in Giardia using CRISPRi

SG McInally, KD Hagen, C Nosala… - Molecular biology of …, 2019 - Am Soc Cell Biol
Giardia lamblia is a binucleate protistan parasite causing significant diarrheal disease
worldwide. An inability to target Cas9 to both nuclei, combined with the lack of nonhomologous …

[HTML][HTML] Eight unique basal bodies in the multi-flagellated diplomonad Giardia lamblia

SG McInally, SC Dawson - Cilia, 2016 - Springer
Giardia lamblia is an intestinal parasitic protist that causes significant acute and chronic
diarrheal disease worldwide. Giardia belongs to the diplomonads, a group of protists in the …

Giardia Colonizes and Encysts in High-Density Foci in the Murine Small Intestine

NR Barash, C Nosala, JK Pham, SG McInally… - MSphere, 2017 - Am Soc Microbiol
Giardia lamblia is a highly prevalent yet understudied protistan parasite causing significant
diarrheal disease worldwide. Hosts ingest Giardia cysts from contaminated sources. In the …

Length-dependent disassembly maintains four different flagellar lengths in Giardia

SG McInally, J Kondev, SC Dawson - Elife, 2019 - elifesciences.org
With eight flagella of four different lengths, the parasitic protist Giardia is an ideal model to
evaluate flagellar assembly and length regulation. To determine how four different flagellar …

[HTML][HTML] Harnessing the power of new genetic tools to illuminate Giardia biology and pathogenesis

KD Hagen, CJS Hart, SG McInally, SC Dawson - Genetics, 2024 - academic.oup.com
Giardia is a prevalent single-celled microaerophilic intestinal parasite causing diarrheal
disease and significantly impacting global health. Double diploid (essentially tetraploid) Giardia …

Scaling of subcellular actin structures with cell length through decelerated growth

SG McInally, J Kondev, BL Goode - Elife, 2021 - elifesciences.org
How cells tune the size of their subcellular parts to scale with cell size is a fundamental
question in cell biology. Until now, most studies on the size control of organelles and other …

Quantitative analysis of actin cable length in yeast

SG McInally, J Kondev, BL Goode - Bio-protocol, 2022 - bio-protocol.org
… Therefore, cable length is determined by a balance between these two simultaneous competing
effects (McInally et al., … This protocol was developed and used in a recent study (McInally

[HTML][HTML] Length control emerges from cytoskeletal network geometry

SG McInally, AJB Reading, A Rosario, PR Jelenkovic… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Many cytoskeletal networks consist of individual filaments that are organized into elaborate
higher order structures. While it is appreciated that the size and architecture of these …

Affinity-purified Plasmodium tubulin provides a key reagent for antimalarial drug development

SG McInally, SC Dawson - Trends in Parasitology, 2022 - cell.com
Hirst et al. used a TOG-domain-based affinity-purification approach to reconstitute and define
the in vitro dynamics of blood-stage Plasmodium falciparum αβ-tubulin. This provides a key …