General cognitive function is a prominent and relatively stable human trait that is associated
with many important life outcomes. We combine cognitive and genetic data from the …

Major depression is a debilitating psychiatric illness that is typically associated with low
mood and anhedonia. Depression has a heritable component that has remained difficult to …

Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-wide
association study of 41,917 bipolar disorder cases and 371,549 controls of European …

Depression is a polygenic trait that causes extensive periods of disability. Previous genetic
studies have identified common risk variants which have progressively increased in number …

Alzheimer’s disease (AD) is a public health priority for the 21st century. Risk reduction currently
revolves around lifestyle changes with much research trying to elucidate the biological …

Quantifying the microstructural properties of the human brain’s connections is necessary for
understanding normal ageing and disease. Here we examine brain white matter magnetic …

People’s differences in cognitive functions are partly heritable and are associated with important
life outcomes. Previous genome-wide association (GWA) studies of cognitive functions …

Causes of the well-documented association between low levels of cognitive functioning and
many adverse neuropsychiatric outcomes, poorer physical health and earlier death remain …

Neuroticism is a relatively stable personality trait characterized by negative emotionality (for
example, worry and guilt) 1 ; heritability estimated from twin studies ranges from 30 to 50% 2 …

Intelligence, or general cognitive function, is phenotypically and genetically correlated with
many traits, including a wide range of physical, and mental health variables. Education is …