Type I interferons are effector cytokines essential for the regulation of the innate immunity. A
key effector of the type I interferon response that is dysregulated in autoimmunity and cancer …

The cGAS-STING (cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING))
axis integrates DNA damage and cellular stress with type I interferon (IFN) signalling to …

We are in unprecedented times with the ongoing COVID-19 pandemic. The pandemic has
impacted public health, the economy and our society on a global scale. In addition, the …

The nucleus harbours numerous protein subdomains and condensates that regulate chromatin
organization, gene expression and genomic stress. A novel nuclear subdomain that is …

There is now increasing evidence for the importance of microbial regulation of biogeochemical
cycling in streams. Resource availability shapes microbial community structure, but less …

Ceroid lipofuscinosis neuronal 5 (CLN5) is a member of a family of proteins that are linked
to neuronal ceroid lipofuscinosis (NCL). This devastating neurological disorder, known …

SARS-CoV-2 (Severe Acute Respiratory Syndrome coronavirus 2) has been reported to infect
domesticated animals in a species-specific manner, where cats were susceptible but not …

We have uncovered a role for the promyelocytic leukemia (PML) gene and novel PML-like
DEDDh exonucleases in the maintenance of genome stability through the restriction of LINE-1 …

Mutations in CLN5 cause a subtype of neuronal ceroid lipofuscinosis (NCL) called CLN5
disease. While the precise role of CLN5 in NCL pathogenesis is not known, recent work …

Mutations in CLN3 cause a juvenile form of neuronal ceroid lipofuscinosis (NCL), commonly
known as Batten disease. Currently, there is no cure for NCL and the mechanisms …