The adhesive interactions of cells with their environment through the integrin family of
transmembrane receptors have key roles in regulating multiple aspects of cellular physiology, …

The talin-vinculin axis is a key mechanosensing component of cellular focal adhesions.
How talin and vinculin respond to forces and regulate one another remains unclear. By …

Abstract Analysis of 501 melanoma exomes identified RASA2, encoding a RasGAP, as a
tumor-suppressor gene mutated in 5% of melanomas. Recurrent loss-of-function mutations in …

Podosomes, which are formed by different monocyte derivatives, are small adhesion
structures whose coordinated dynamics and cytoskeletal reorganization drive their motile and …

Cancer immunotherapy focuses on inhibitors of checkpoint proteins, such as programmed
death ligand 1 (PD-L1). Unlike RAS-mutated lung cancers, EGFR mutant tumors have a …

High‐content image‐based cell phenotyping provides fundamental insights into a broad
variety of life science disciplines. Striving for accurate conclusions and meaningful impact …

Cell adhesion to the extracellular matrix is mediated by elaborate networks of multiprotein
complexes consisting of adhesion receptors, cytoskeletal components, signaling molecules, …

Homozygosity for the R51Q mutation in sorting nexin 10 (SNX10) inactivates osteoclasts (OCLs)
and induces autosomal recessive osteopetrosis in humans and in mice. We show here …

The interface between the cellular actin network and diverse forms of integrin-mediated cell
adhesions displays a unique capacity to serve as accurate chemical and mechanical …

In this article, we discuss the complex involvement of a Rho-family GTPase, Rac1, in cell
migration and in invadopodia-mediated matrix degradation. We discuss the involvement of …