Environmental stimuli often lead to heterogeneous cellular responses and transcriptional
output. We developed single-cell RNA and Immunodetection (RAID) to allow combined …

Immuno-PCR combines specific antibody-based protein detection with the sensitivity of PCR-based
quantification through the use of antibody-DNA conjugates. The production of such …

Transcription factor p63 is a key regulator of epidermal keratinocyte proliferation and
differentiation. Mutations in the p63 DNA-binding domain are associated with ectrodactyly, …

Epidermal homeostasis requires balanced progenitor cell proliferation and loss of differentiated
cells from the epidermal surface. During this process, cells undergo major changes in …

The brittle hair syndrome Trichothiodystrophy (TTD) is characterized by variable clinical
features, including photosensitivity, ichthyosis, growth retardation, microcephaly, intellectual …

Cell-based small molecule screening is an effective strategy leading to new medicines.
Scientists in the pharmaceutical industry as well as in academia have made tremendous …

As our understanding of transcriptional regulation improves so does our appreciation of its
complexity. Both coding and (long) non-coding RNAs provide cells with multiple levels of …

Epidermal homeostasis requires balanced and coordinated adult stem cell renewal and
differentiation. These processes are controlled by both extracellular signaling and by cell …

Cell-based small molecule screening is an effective strategy leading to new medicines.
Scientists in the pharmaceutical industry as well as in academia have made tremendous …

Epidermal homeostasis requires a continuous balance between progenitor cell proliferation
and loss of differentiated cells from its surface. During this process cells undergo major …