Ribosomes are specialized entities that participate in regulation of gene expression through
their rRNAs carrying ribozyme activity. Ribosome biogenesis is overactivated in p53-…

NLRP3 controls the secretion of inflammatory cytokines IL-1β/18 and pyroptosis by assembling
the inflammasome. Upon coordinated priming and activation stimuli, NLRP3 recruits …

Highly conserved during evolution, the ribosome is the central effector of protein synthesis.
In mammalian cells, the ribosome is a macromolecular complex composed of four different …

Netrin-1 displays proto-oncogenic activity in several cancers, which is thought to be due to
the ability of this secreted cue to stimulate survival when bound to its receptors. We showed …

Many studies highlight the potential link between the chronic degenerative Alzheimer’s
disease and the infection by the herpes simplex virus type-1 (HSV-1). However, the molecular …

Herpes simplex virus type 1 (HSV-1) infection induces profound nucleolar modifications at the
functional and organizational levels, including nucleolar invasion by several viral proteins. …

Influenza viruses replicate their single-stranded RNA genomes in the nucleus of infected
cells and these replicated genomes (vRNPs) are then exported from the nucleus to the …

Nucleoli are now recognized as multi‐functional nuclear domains involved in several
fundamental cell processes such as ribosome biogenesis, regulation of the assembly of non‐…

The nucleolar proteins which link cell proliferation to ribosome biogenesis are regarded to
be potentially oncogenic. Here, in order to examine the involvement of an evolutionary …

Homeodomain-interacting protein kinase 2 (HIPK2) is a nuclear serine/threonine kinase of
the subfamily of dual-specificity Yak1-related kinase proteins. HIPK2 was first described as a …