Synapses are often far from the soma and independently cope with proteopathic stress induced
by intense neuronal activity. However, how presynaptic compartments turn over proteins …

Exchange of proteins at sorting endosomes is not only critical to numerous signaling pathways
but also to receptor-mediated signaling and to pathogen entry into cells; however, how …

Presynaptic terminals are metabolically active and accrue damage through continuous
vesicle cycling. How synapses locally regulate protein homeostasis is poorly understood. We …

Synapses are often far from their cell bodies and must largely independently cope with
dysfunctional proteins resulting from synaptic activity and stress. To identify membrane-…

Synaptic vesicle reformation depends on clathrin, an abundant protein that polymerizes
around newly forming vesicles. However, how clathrin is involved in synaptic recycling in vivo …

ATP production requires the establishment of an electrochemical proton gradient across the
inner mitochondrial membrane. Mitochondrial uncouplers dissipate this proton gradient and …

PI(3,4,5)P 3 is a low-abundance lipid thought to play a role in the regulation of synaptic
activity; however, the mechanism remains obscure. We have constructed novel split Venus-…

Synaptic demise and accumulation of dysfunctional proteins are thought of as common
features in neurodegeneration. However, the mechanisms by which synaptic proteins turn over …

Studying gene function in the post-genome era requires methods to localize and inactivate
proteins in a standardized fashion in model organisms. While genome-wide gene disruption …

Mutations in succinate dehydrogenase (SDH) are associated with tumor development and
neurodegenerative diseases. Only in tumors, loss of SDH activity is accompanied with the …