Background Although ZnO nanoparticles (NPs) are used in many commercial products and
the potential for human exposure is increasing, few in vivo studies have addressed their …

Reliable and versatile hepatic in vitro systems for the prediction of drug pharmacokinetics
and toxicity are essential constituents of preclinical safety assessment pipelines for new …

High failure rates of drug candidates in the clinics, restricted-use warnings as well as
withdrawals of drugs in postmarketing stages are of substantial concern for the pharmaceutical …

Adverse reactions or lack of response to medications are important concerns for drug
development programs. However, faithful predictions of drug metabolism and toxicity are difficult …

Cancer-associated fibroblasts (CAF) stimulate tumor growth and metastasis. Signals
supporting CAF function are thus emerging as candidate therapeutic targets in the tumor …

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates
many of the responses to toxic environmental chemicals such as TCDD or dioxin-like PCBs. …

Hepatocytes are dynamic cells that, upon injury, can alternate between nondividing differentiated
and dedifferentiated proliferating states in vivo. However, in two‐dimensional cultures, …

The liver fulfills central roles in metabolic control and detoxification and, as such, is continuously
exposed to a plethora of insults. Importantly, the liver has a unique ability to regenerate …

The aryl hydrocarbon receptor (AhR) is an important mediator of toxic responses after
exposure to xenobiotics including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and dioxin-like …

Marburg and Ebola filoviruses are two of the deadliest infectious agents and several outbreaks
have occurred in the last decades. Although several receptors and co-receptors have …