[PDF][PDF] Clinical outcomes of early treatment with doxycycline for 89 high-risk COVID-19 patients in long-term care facilities in New York

MM Alam, S Mahmud, MM Rahman, JA Simpson… - Cureus, 2020 - cureus.com
Rationale Due to the cluster and associated comorbidities in residents of long-term care
facilities (LTCFs), COVID-19-associated morbidity and mortality are significantly increased. …

[HTML][HTML] Loss of E-cadherin is causal to pathologic changes in chronic lung disease

…, D Chen, C Swaby, S Chen, S Mahmud… - Communications …, 2022 - nature.com
Epithelial cells line the lung mucosal surface and are the first line of defense against toxic
exposures to environmental insults, and their integrity is critical to lung health. An early finding …

Epithelial plasticity in COPD results in cellular unjamming due to an increase in polymerized actin

…, K Nishida, L Chandrala, S Mahmud… - Journal of cell …, 2022 - journals.biologists.com
The airway epithelium is subjected to insults such as cigarette smoke (CS), a primary cause
of chronic obstructive pulmonary disease (COPD) and serves as an excellent model to study …

Doxycycline and hydroxychloroquine as treatment for high-risk COVID-19 patients: experience from case series of 54 patients in long-term care facilities

I Ahmad, M Alam, R Saadi, S Mahmud, E Saadi - MedRxiv, 2020 - medrxiv.org
Importance Patients in long-term care facilities (LTCF) are at a high-risk of contracting
COVID-19 due to advanced age and multiple comorbidities. Without effective treatments, …

[PDF][PDF] Clinical impact of the early use of monoclonal antibody LY-CoV555 (bamlanivimab) on mortality and hospitalization among elderly nursing home patients: a …

MM Alam, S Mahmud, S Aggarwal, S Fathma… - Cureus, 2021 - cureus.com
Importance Coronavirus disease 2019 (COVID-19) outbreaks are frequent occurrences in
nursing homes and long-term care facilities (LTCFs), resulting in subsequent hospitalization …

Quantifying epithelial plasticity as a platform to reverse epithelial injury

K Nishida, B Ghosh, L Chandrala, S Mahmud, S Chen… - bioRxiv, 2020 - biorxiv.org
Epithelial surfaces lining the lung serve as the primary environmental gaseous interface,
and are subject to common life-limiting diseases, including COPD (Chronic Obstructive …

Knockout of E-cadherin in adult mouse epithelium results in emphysema and airway disease

B Ghosh, J Loube, S Thapa, E Capodanno, S Mahmud… - bioRxiv, 2021 - biorxiv.org
Chronic obstructive pulmonary disease (COPD) is a devastating lung disease, characterized
by a progressive decline in lung function, alveolar loss (emphysema), and airflow limitation …

Epithelial Plasticity in COPD Epithelia Is Associated with Mitochondrial Dysfunction

…, K Nishida, L Chandrala, S Mahmud… - The FASEB …, 2021 - Wiley Online Library
Cellular plasticity is generally defined as the ability of a cell to adapt in response to stimuli.
The airway epithelium is subjected to chronic environmental insults and therefore serves as …

[PDF][PDF] Comparison of Duration of Bacteremia and Mortality with Methicillin-Resistant Staphylococcus aureus (MRSA) vs Methicillin-Susceptible Staphylococcus …

…, MD Siddiqi Haque, MPH Saborny Mahmud - … BASIS, SYMPTOMS AND … - bapainfo.org
It has been suggested that MRSA bacteremia is associated with a higher mortality rate than
MSSA bacteremia, perhaps due to decreased effectiveness of antibiotics. However, to our …

[HTML][HTML] SARS-CoV-2 and Therapeutic Approaches

D Chugh, M Bishnoi - The Open COVID Journal, 2022 - opencovidjournal.com
In 2019, the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) was first reported
in Wuhan, China, affecting the population all over the globe. This ongoing pandemic is …