User profiles for Sabrina Lusvarghi
Sabrina Lusvarghi, PhDFDA Verified email at fda.hhs.gov Cited by 1471 |
SARS-CoV-2 BA. 1 variant is neutralized by vaccine booster–elicited serum but evades most convalescent serum and therapeutic antibodies
S Lusvarghi, SD Pollett, SN Neerukonda… - Science Translational …, 2022 - science.org
The rapid spread of the highly contagious Omicron variant of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) along with its high number of mutations in the spike gene …
coronavirus 2 (SARS-CoV-2) along with its high number of mutations in the spike gene …
[PDF][PDF] Antigenic cartography of well-characterized human sera shows SARS-CoV-2 neutralization differences based on infection and vaccination history
W Wang, S Lusvarghi, R Subramanian, NJ Epsi… - Cell host & …, 2022 - cell.com
The rapid emergence of SARS-CoV-2 variants challenges vaccination strategies. Here, we
collected 201 serum samples from persons with a single infection or multiple vaccine …
collected 201 serum samples from persons with a single infection or multiple vaccine …
[HTML][HTML] The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants
…, W Li, W Du, HK Binz, R Herrup, S Lusvarghi… - Nature …, 2022 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
with potential resistance to existing drugs emphasizes the need for new therapeutic …
with potential resistance to existing drugs emphasizes the need for new therapeutic …
[HTML][HTML] Griffithsin: an antiviral lectin with outstanding therapeutic potential
S Lusvarghi, CA Bewley - Viruses, 2016 - mdpi.com
Griffithsin (GRFT), an algae-derived lectin, is one of the most potent viral entry inhibitors
discovered to date. It is currently being developed as a microbicide with broad-spectrum activity …
discovered to date. It is currently being developed as a microbicide with broad-spectrum activity …
[HTML][HTML] SARS-CoV-2 Omicron neutralization by therapeutic antibodies, convalescent sera, and post-mRNA vaccine booster
The rapid spread of the highly contagious Omicron variant of SARS-CoV-2 along with its high
number of mutations in the spike gene has raised alarm about the effectiveness of current …
number of mutations in the spike gene has raised alarm about the effectiveness of current …
Synthesis, stereoelectronic characterization and antiparasitic activity of new 1-benzenesulfonyl-2-methyl-1, 2, 3, 4-tetrahydroquinolines
RJ Pagliero, S Lusvarghi, AB Pierini, R Brun… - Bioorganic & medicinal …, 2010 - Elsevier
The synthesis and full 3D structural characterization of nine new 1-benzenesulfonyl-2-methyl-1,2,3,4-tetrahydroquinoline
derivatives are reported. These belong to a library whose …
derivatives are reported. These belong to a library whose …
Avapritinib: a selective inhibitor of KIT and PDGFRα that reverses ABCB1 and ABCG2-mediated multidrug resistance in cancer cell lines
CP Wu, S Lusvarghi, JC Wang, SH Hsiao… - Molecular …, 2019 - ACS Publications
The frequent occurrence of multidrug resistance (MDR) conferred by the overexpression of
ATP-binding cassette (ABC) transporters ABCB1 and ABCG2 in cancer cells remains a …
ATP-binding cassette (ABC) transporters ABCB1 and ABCG2 in cancer cells remains a …
Key substitutions in the spike protein of SARS-CoV-2 variants can predict resistance to monoclonal antibodies, but other substitutions can modify the effects
S Lusvarghi, W Wang, R Herrup… - Journal of …, 2022 - Am Soc Microbiol
Mutations in the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
variants can compromise the effectiveness of therapeutic antibodies. Most clinical-…
variants can compromise the effectiveness of therapeutic antibodies. Most clinical-…
[HTML][HTML] Targeted isolation of antibodies directed against major sites of SIV Env vulnerability
…, T Zhou, R Nguyen, S O'Dell, S Lusvarghi… - PLoS …, 2016 - journals.plos.org
The simian immunodeficiency virus (SIV) challenge model of lentiviral infection is often used
as a model to human immunodeficiency virus type 1 (HIV-1) for studying vaccine mediated …
as a model to human immunodeficiency virus type 1 (HIV-1) for studying vaccine mediated …
Characterization of entry pathways, species-specific angiotensin-converting enzyme 2 residues determining entry, and antibody neutralization evasion of omicron BA …
…, R Wang, R Vassell, H Baha, S Lusvarghi… - Journal of …, 2022 - Am Soc Microbiol
The SARS-CoV-2 Omicron variants were first detected in November 2021, and several
Omicron lineages (BA.1, BA.2, BA.3, BA.4, and BA.5) have since rapidly emerged. Studies …
Omicron lineages (BA.1, BA.2, BA.3, BA.4, and BA.5) have since rapidly emerged. Studies …