Multisite phosphorylation of the PERIOD 2 (PER2) protein is the key step that determines the
period of the mammalian circadian clock. Previous studies concluded that an unidentified …

Post-translational control of PERIOD stability by Casein Kinase 1δ and ε (CK1) plays a key
regulatory role in metazoan circadian rhythms. Despite the deep evolutionary conservation of …

PERIOD (PER) and Casein Kinase 1δ regulate circadian rhythms through a phosphoswitch
that controls PER stability and repressive activity in the molecular clock. CK1δ …

Bafilomycin A 1 is a specific inhibitor of the vacuolar-ATPase (V-ATPase), which is responsible
for pH homeostasis of the cell and for the acidification of endosomes. Bafilomycin A 1 has …

Post-translational control of PERIOD stability by Casein Kinase 1δ and ε (CK1) plays a key
regulatory role in metazoan circadian rhythms. Despite the deep evolutionary conservation of …

Monday, February 17, 2020 207a conformation of the activation loop on the kinase domain,
which could be responsible for enhanced Degron activity and decreased FASP activity, as …

The mammalian circadian clock is a transcription-translation feedback loop that governs a
variety of behavioral and physiological processes with approximately 24-hour periodicity. One …

Students' writing ability has become an essential element for student success and may be
influenced by the student and teachers skills; therefore, the subject has garnered the attention …

NMR is a powerful technique that provides a method of determine the three-dimensional
structure of macromolecules in solution. Structure determination using NMR requires manual …

Students’ writing ability has become an essential element for student success and may be
influenced by the student and teachers skills; therefore, the subject has garnered the attention …