Dynamic three-dimensional chromatin conformation is a critical mechanism for gene regulation
during development and disease. Despite this, profiling of three-dimensional genome …

Chromatin is folded into successive layers to organize linear DNA. Genes within the same
topologically associating domains (TADs) demonstrate similar expression and histone-…

Higher-order chromatin structure is important for the regulation of genes by distal regulatory
sequences 1 , 2 . Structural variants (SVs) that alter three-dimensional (3D) genome …

Neurons are the longest-lived cells in our bodies and lack DNA replication, which makes
them reliant on a limited repertoire of DNA repair mechanisms to maintain genome fidelity. …

Pathological obesity can result from genetic predisposition, obesogenic diet, and circadian
rhythm disruption. Obesity compromises function of muscle, which accounts for a majority of …

Circular extrachromosomal DNA (ecDNA) in patient tumors is an important driver of oncogenic
gene expression, evolution of drug resistance and poor patient outcomes. Applying …

During mitosis, transcription of genomic DNA is dramatically reduced, before it is reactivated
during nuclear reformation in anaphase/telophase. Many aspects of the underlying …

Ependymoma is a tumor of the brain or spinal cord. The two most common and aggressive
molecular groups of ependymoma are the supratentorial ZFTA-fusion associated and the …

In the published version of this paper, the members of the Pan-Cancer Analysis of Whole
Genomes (PCAWG) Consortium were listed in the Supplementary Information; however, these …

Mutations in the human LMNA gene cause a collection of diseases known as laminopathies.
These include myocardial diseases that exhibit age‐dependent penetrance of …