DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia
…, CY Taabazuing, MC Okondo, AJ Chui, SD Rao… - Nature medicine, 2018 - nature.com
Small-molecule inhibitors of the serine dipeptidases DPP8 and DPP9 (DPP8/9) induce a lytic
form of cell death called pyroptosis in mouse and human monocytes and macrophages 1 , …
form of cell death called pyroptosis in mouse and human monocytes and macrophages 1 , …
N-terminal degradation activates the NLRP1B inflammasome
AJ Chui, MC Okondo, SD Rao, K Gai, AR Griswold… - Science, 2019 - science.org
Intracellular pathogens and danger signals trigger the formation of inflammasomes, which
activate inflammatory caspases and induce pyroptosis. The anthrax lethal factor …
activate inflammatory caspases and induce pyroptosis. The anthrax lethal factor …
[PDF][PDF] Inhibition of Dpp8/9 activates the Nlrp1b inflammasome
MC Okondo, SD Rao, CY Taabazuing, AJ Chui… - Cell chemical …, 2018 - cell.com
Val-boroPro (PT-100, Talabostat) induces powerful anti-tumor immune responses in syngeneic
cancer models, but its mechanism of action has not yet been established. Val-boroPro is …
cancer models, but its mechanism of action has not yet been established. Val-boroPro is …
[HTML][HTML] DPP8/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes
DC Johnson, MC Okondo, EL Orth, SD Rao… - Cell death & …, 2020 - nature.com
Canonical inflammasomes are innate immune signaling platforms that are formed in response
to intracellular pathogen-associated signals and trigger caspase-1-dependent pyroptosis. …
to intracellular pathogen-associated signals and trigger caspase-1-dependent pyroptosis. …
Caspase-1 interdomain linker cleavage is required for pyroptosis
…, AR Griswold, EL Orth, SD Rao… - Life science …, 2020 - life-science-alliance.org
Pathogen-related signals induce a number of cytosolic pattern-recognition receptors (PRRs)
to form canonical inflammasomes, which activate pro-caspase-1 and trigger pyroptotic cell …
to form canonical inflammasomes, which activate pro-caspase-1 and trigger pyroptotic cell …
[HTML][HTML] DPP8/9 inhibitors are universal activators of functional NLRP1 alleles
Intracellular pathogenic structures or activities stimulate the formation of inflammasomes,
which recruit and activate caspase-1 and trigger an inflammatory form of cell death called …
which recruit and activate caspase-1 and trigger an inflammatory form of cell death called …
[PDF][PDF] Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation
NLRP1 and CARD8 are related pattern-recognition receptors (PRRs) that detect intracellular
danger signals and form inflammasomes. Both undergo autoproteolysis, generating N-…
danger signals and form inflammasomes. Both undergo autoproteolysis, generating N-…
[PDF][PDF] A chemical strategy for protease substrate profiling
The dipeptidyl peptidases (DPPs) regulate hormones, cytokines, and neuropeptides by
cleaving dipeptides after proline from their amino termini. Due to technical challenges, many …
cleaving dipeptides after proline from their amino termini. Due to technical challenges, many …
DPP9's enzymatic activity and not its binding to CARD8 inhibits inflammasome activation
Inflammasomes are multiprotein complexes formed in response to pathogens. NLRP1 and
CARD8 are related proteins that form inflammasomes, but the pathogen-associated signal(s) …
CARD8 are related proteins that form inflammasomes, but the pathogen-associated signal(s) …
M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome
Inflammasomes are multiprotein complexes that sense intracellular danger signals and
induce pyroptosis. CARD8 and NLRP1 are related inflammasomes that are repressed by the …
induce pyroptosis. CARD8 and NLRP1 are related inflammasomes that are repressed by the …