User profiles for Sahil Pontula

Sahil Pontula

Graduate Student, Massachusetts Institute of Technology
Verified email at mit.edu
Cited by 171

Self-assembling nucleic acid nanostructures functionalized with aptamers

A Krissanaprasit, CM Key, S Pontula… - Chemical …, 2021 - ACS Publications
Researchers have worked for many decades to master the rules of biomolecular design that
would allow artificial biopolymer complexes to self-assemble and function similarly to the …

Genetically encoded, functional single‐strand RNA origami: anticoagulant

…, C Key, M Fergione, K Froehlich, S Pontula… - Advanced …, 2019 - Wiley Online Library
Nucleic acid aptamers selected for thrombin binding have been previously shown to possess
anticoagulant activity; however, problems with rapid renal clearance and short circulation …

Multivalent Aptamer‐Functionalized Single‐Strand RNA Origami as Effective, Target‐Specific Anticoagulants with Corresponding Reversal Agents

…, CM Key, K Froehlich, S Pontula… - Advanced …, 2021 - Wiley Online Library
Anticoagulants are commonly utilized during surgeries and to treat thrombotic diseases like
stroke and deep vein thrombosis. However, conventional anticoagulants have serious side‐…

“Worst-case” microlensing in the identification and modeling of lensed quasars

…, PL Schechter, S Pontula - The Astrophysical …, 2021 - iopscience.iop.org
Although microlensing of macrolensed quasars and supernovae provides unique opportunities
for several kinds of investigations, it can add unwanted and sometimes substantial noise. …

Strong intensity noise condensation using nonlinear dispersive loss in semiconductor lasers

S Pontula, J Sloan, N Rivera, M Soljacic - arXiv preprint arXiv:2212.07300, 2022 - arxiv.org
Fock states are the most fundamental quantum states of light, as they are eigenstates of the
electromagnetic field Hamiltonian. They underlie numerous quantum information protocols …

Enhanced Anticoagulation Activity of Functional RNA Origami

A Krissanaprasit, CM Key, K Froehlich, S Pontula… - BioRxiv, 2020 - biorxiv.org
Anticoagulants are commonly utilized during surgeries and to treat thrombotic diseases like
stroke and deep vein thrombosis. However, conventional anticoagulants have serious side-…

Developing and Characterizing Sources of Quantum States of Light: from Single Photons to Million-Photon Fock States

S Pontula - 2023 - dspace.mit.edu
One of the central goals of quantum optics is the generation and control of quantum states
of light. Chief among these states are Fock states, the fundamental eigenstates of the …

Strong quantum mechanical squeezing based on nonlinear dispersive loss in semiconductor lasers

S Pontula, J Sloan, N Rivera… - 2023 Conference on …, 2023 - ieeexplore.ieee.org
We predict that a combination of frequency-dependent outcoupling and optical nonlinearity
in semiconductor lasers can create sharply intensity-dependent loss that squeezes intensity …

Normalizing Flows for Multimodal and Extended-Mode Lattice Field Theories

S Pontula, D Hackett… - APS April Meeting …, 2023 - ui.adsabs.harvard.edu
Probability distributions are ubiquitous in physics and form the basis for our descriptions of
quantum and statistical systems. For example, the field of lattice quantum field theory …

[PDF][PDF] Genetically Encoding Functional RNA Origami: Anticoagulant

C Key, K Froehlich, M Fergione, S Pontula… - Support of the …, 2020 - apps.dtic.mil
Anticoagulants disrupt the coagulation cascade to prevent the formation of blood clots that
can restrict blood flow to vital organs. However, current anticoagulants, such as warfarin and …