Single-cell RNA sequencing of psoriatic skin identifies pathogenic Tc17 cell subsets and reveals distinctions between CD8+ T cells in autoimmunity and cancer

…, HW Chang, ZM Huang, M Nakamura, S Sekhon… - Journal of Allergy and …, 2021 - Elsevier
Background Psoriasis is an inflammatory, IL-17–driven skin disease in which autoantigen-induced
CD8 + T cells have been identified as pathogenic drivers. Objective Our study …

Monoclonal antibodies inhibiting IL-12,-23, and-17 for the treatment of psoriasis

C Jeon, S Sekhon, D Yan, L Afifi… - Human vaccines & …, 2017 - Taylor & Francis
Psoriasis is a chronic, inflammatory, immune-mediated skin condition that affects 3 to 4% of
the adult US population, characterized by well-demarcated, erythematous plaques with silver …

The impact of pediatric atopic dermatitis on families: a review

EJ Yang, KM Beck, S Sekhon, T Bhutani… - Pediatric …, 2019 - Wiley Online Library
Background Atopic dermatitis (AD) is an extremely common childhood disease, with considerable
impact on the quality of life of affected children and their families. While pruritus is the …

[HTML][HTML] Frequency and management of sleep disturbance in adults with atopic dermatitis: a systematic review

C Jeon, D Yan, M Nakamura, S Sekhon… - Dermatology and …, 2017 - Springer
Introduction Intense nocturnal pruritus as well as the complex pathophysiology of atopic
dermatitis (AD) can severely affect sleep and become a major factor in negatively impacting …

Dupilumab treatment for generalized prurigo nodularis

KM Beck, EJ Yang, S Sekhon, T Bhutani… - JAMA …, 2019 - jamanetwork.com
Methods In this case series, 3 patients with generalized prurigo nodularis seen at the
dermatology practice of a hospital-based tertiary referral center were evaluated and treated …

[HTML][HTML] Guselkumab for the treatment of psoriasis: a review of phase III trials

M Nakamura, K Lee, C Jeon, S Sekhon, L Afifi… - Dermatology and …, 2017 - Springer
Introduction Interleukin (IL)-23 inhibitors are a new class of biologics currently undergoing
clinical trials for the treatment of moderate-to-severe psoriasis. Phase III studies of guselkumab…

Review of the mechanism of action of coal tar in psoriasis

S Sekhon, C Jeon, M Nakamura, L Afifi… - Journal of …, 2018 - Taylor & Francis
Purpose: Crude coal tar and its derivatives have been used in modern medicine for the
treatment of psoriasis since at least 1925 as part of the Goeckerman regimen. To this day, coal …

Recent developments in atopic dermatitis

EJ Yang, S Sekhon, IM Sanchez, KM Beck… - Pediatrics, 2018 - publications.aap.org
Pediatricians are often the first physicians to diagnose and manage these patients and thus
are relied on by families to answer questions about this disease. AD is complex, multifactorial…

Non-pharmacologic approaches for hidradenitis suppurativa–a systematic review

AJ Hendricks, PA Hirt, S Sekhon… - Journal of …, 2021 - Taylor & Francis
Importance: Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition presenting
with painful nodules and sinus tracts primarily in intertriginous regions. The persistent …

[HTML][HTML] Generalized pustular psoriasis treated with apremilast in a patient with multiple medical comorbidities

C Jeon, M Nakamura, S Sekhon, D Yan… - JAAD case …, 2017 - jaadcasereports.org
Discussion The current treatment options for GPP include first-line therapies of cyclosporine,
methotrexate, acitretin, and infliximab, as well as second-line therapies of adalimumab …