INTRODUCTION Sex differences are widespread in humans and other mammals. For example,
the distribution of height or body size is shifted upwards in males relative to females, and …

Evidence from model organisms and clinical genetics suggests coordination between the
developing brain and face, but the role of this link in common genetic variation remains …

Variations in the form of the human face, which plays a role in our individual identities and
societal interactions, have fascinated scientists and artists alike. Here, we review our current …

Gene regulatory divergence is thought to play a central role in determining human-specific
traits. However, our ability to link divergent regulation to divergent phenotypes is limited. Here…

Most signals in genome-wide association studies (GWAS) of complex traits implicate
noncoding genetic variants with putative gene regulatory effects. However, currently identified …

Genome-wide association studies (GWAS) have been used to study the genetic basis of a
wide variety of complex diseases and other traits. We describe UK Biobank GWAS results for …

Transcriptional regulation exhibits extensive robustness, but human genetics indicates sensitivity
to transcription factor (TF) dosage. Reconciling such observations requires quantitative …

Most signals in genome-wide association studies (GWAS) of complex traits point to
noncoding genetic variants with putative gene regulatory effects. However, currently identified …

The human face is complex and multipartite, and characterization of its genetic architecture
remains challenging. Using a multivariate genome-wide association study meta-analysis of …

Gene regulatory networks ensure that important genes are expressed at precise levels. When
gene expression is sufficiently perturbed, it can lead to disease. To understand how gene …