In humans, the 25 bitter taste receptors (T2Rs) are activated by hundreds of structurally
diverse bitter compounds. However, only five antagonists or bitter blockers are known. In this …

Obesity is the major driver of the global epidemic in type 2 diabetes (T2D). In individuals
with obesity, impaired insulin action leads to increased lipolysis in adipocytes, resulting in …

β-Arrestins are major regulators of G protein-coupled receptor-mediated signaling processes.
Their potential roles in regulating adipocyte function in vivo remain unexplored. Here we …

The incidence of obesity and type 2 diabetes (T2D) has been increasing steadily worldwide.
It is estimated that by 2045 more than 800 million people will be suffering from diabetes. …

Adipocyte dysfunction links obesity to insulin resistance and type 2 diabetes. Adipocyte function
is regulated by receptor-mediated activation of heterotrimeric G proteins. Little is known …

β-Arrestin-1 and -2 (also known as arrestin-2 and -3, respectively) are ubiquitously
expressed cytoplasmic proteins that dampen signaling through G protein–coupled receptors. …

G protein–coupled receptors (GPCRs) form a superfamily of plasma membrane receptors that
couple to four major families of heterotrimeric G proteins, G s , G i , G q , and G 12 . GPCRs …

Bitter taste receptors (T2Rs) belong to the G protein-coupled receptor superfamily. In humans,
25 T2Rs mediate bitter taste sensation. In addition to the oral cavity, T2Rs are expressed …

Uridine diphosphate (UDP)-activated purinergic receptor P2Y 6 (P2Y 6 R) plays a crucial
role in controlling energy balance through central mechanisms. However, P2Y 6 R’s roles in …

Aim Thrombospondins are a family of multidomain and secretory glycoproteins. Among them,
thrombospondin 2 (TSP2) encoded by TSP2 gene has been reported to be involved in …