User profiles for Sailesh Malla
Sailesh MallaChr. Hansen A/S, Hørshlom Denmark Verified email at chr-hansen.com Cited by 1094 |
[HTML][HTML] Novel biosensors based on flavonoid-responsive transcriptional regulators introduced into Escherichia coli
This study describes the construction of two flavonoid biosensors, which can be applied for
metabolic engineering of Escherichia coli strains. The biosensors are based on …
metabolic engineering of Escherichia coli strains. The biosensors are based on …
Production of 3-O-xylosyl quercetin in Escherichia coli
Quercetin, a flavonol aglycone, is one of the most abundant flavonoids with high medicinal
value. The bioavailability and pharmacokinetic properties of quercetin are influenced by the …
value. The bioavailability and pharmacokinetic properties of quercetin are influenced by the …
Production of 7-O-Methyl Aromadendrin, a Medicinally Valuable Flavonoid, in Escherichia coli
S Malla, MAG Koffas, RJ Kazlauskas… - Applied and …, 2012 - Am Soc Microbiol
7-O-Methyl aromadendrin (7-OMA) is an aglycone moiety of one of the important flavonoid-glycosides
found in several plants, such as Populus alba and Eucalyptus maculata , with …
found in several plants, such as Populus alba and Eucalyptus maculata , with …
[HTML][HTML] Laboratory evolution reveals general and specific tolerance mechanisms for commodity chemicals
Although strain tolerance to high product concentrations is a barrier to the economically
viable biomanufacturing of industrial chemicals, chemical tolerance mechanisms are often …
viable biomanufacturing of industrial chemicals, chemical tolerance mechanisms are often …
[HTML][HTML] Assembly of a novel biosynthetic pathway for production of the plant flavonoid fisetin in Escherichia coli
Plant secondary metabolites are an underutilized pool of bioactive molecules for applications
in the food, pharma and nutritional industries. One such molecule is fisetin, which is …
in the food, pharma and nutritional industries. One such molecule is fisetin, which is …
[HTML][HTML] Limitations in doxorubicin production from Streptomyces peucetius
Doxorubicin (DXR), produced by Streptomyces peucetius ATCC 27952, exhibits potent
antitumor activity against various cancer cell lines. Considerable time has lapsed since the …
antitumor activity against various cancer cell lines. Considerable time has lapsed since the …
[HTML][HTML] Fungal cytochrome P450 monooxygenases of Fusarium oxysporum for the synthesis of ω-hydroxy fatty acids in engineered Saccharomyces cerevisiae
Background Omega hydroxy fatty acids (ω-OHFAs) are multifunctional compounds that act
as the basis for the production of various industrial products with broad commercial and …
as the basis for the production of various industrial products with broad commercial and …
Regiospecific modifications of naringenin for astragalin production in Escherichia coli
We report the production of astragalin (AST) from regiospecific modifications of naringenin (NRN)
in Escherichia coli BL21(DE3). The exogenously supplied NRN was converted into …
in Escherichia coli BL21(DE3). The exogenously supplied NRN was converted into …
[HTML][HTML] Self-resistance mechanism in Streptomyces peucetius: overexpression of drrA, drrB and drrC for doxorubicin enhancement
The resistance genes drrABC from Streptomyces peucetius ATCC 27952 were cloned into
the pIBR25 expression vector under a strong ermE* promoter to enhance doxorubicin (DXR) …
the pIBR25 expression vector under a strong ermE* promoter to enhance doxorubicin (DXR) …
Endothelial cell activation in patients with decompensated heart failure
…, JE Banchs, S Celaj, A Talreja, J Lachmann, S Malla… - Circulation, 2005 - Am Heart Assoc
Background— Vascular endothelial functions, other than nitric oxide (NO)–mediated control
of vasomotor tone, are poorly characterized in patients with chronic heart failure (CHF). …
of vasomotor tone, are poorly characterized in patients with chronic heart failure (CHF). …