User profiles for Sailesh Malla

Sailesh Malla

Chr. Hansen A/S, Hørshlom Denmark
Verified email at chr-hansen.com
Cited by 1094

[HTML][HTML] Novel biosensors based on flavonoid-responsive transcriptional regulators introduced into Escherichia coli

S Siedler, SG Stahlhut, S Malla, J Maury… - Metabolic Engineering, 2014 - Elsevier
This study describes the construction of two flavonoid biosensors, which can be applied for
metabolic engineering of Escherichia coli strains. The biosensors are based on …

Production of 3-O-xylosyl quercetin in Escherichia coli

RP Pandey, S Malla, D Simkhada, BG Kim… - Applied microbiology …, 2013 - Springer
Quercetin, a flavonol aglycone, is one of the most abundant flavonoids with high medicinal
value. The bioavailability and pharmacokinetic properties of quercetin are influenced by the …

Production of 7-O-Methyl Aromadendrin, a Medicinally Valuable Flavonoid, in Escherichia coli

S Malla, MAG Koffas, RJ Kazlauskas… - Applied and …, 2012 - Am Soc Microbiol
7-O-Methyl aromadendrin (7-OMA) is an aglycone moiety of one of the important flavonoid-glycosides
found in several plants, such as Populus alba and Eucalyptus maculata , with …

[HTML][HTML] Laboratory evolution reveals general and specific tolerance mechanisms for commodity chemicals

…, ET Mohammed, PV Phaneuf, MH Noh, S Malla… - Metabolic …, 2023 - Elsevier
Although strain tolerance to high product concentrations is a barrier to the economically
viable biomanufacturing of industrial chemicals, chemical tolerance mechanisms are often …

[HTML][HTML] Assembly of a novel biosynthetic pathway for production of the plant flavonoid fisetin in Escherichia coli

SG Stahlhut, S Siedler, S Malla, SJ Harrison… - Metabolic …, 2015 - Elsevier
Plant secondary metabolites are an underutilized pool of bioactive molecules for applications
in the food, pharma and nutritional industries. One such molecule is fisetin, which is …

[HTML][HTML] Limitations in doxorubicin production from Streptomyces peucetius

S Malla, NP Niraula, B Singh, K Liou, JK Sohng - Microbiological research, 2010 - Elsevier
Doxorubicin (DXR), produced by Streptomyces peucetius ATCC 27952, exhibits potent
antitumor activity against various cancer cell lines. Considerable time has lapsed since the …

[HTML][HTML] Fungal cytochrome P450 monooxygenases of Fusarium oxysporum for the synthesis of ω-hydroxy fatty acids in engineered Saccharomyces cerevisiae

P Durairaj, S Malla, SP Nadarajan, PG Lee… - Microbial Cell …, 2015 - Springer
Background Omega hydroxy fatty acids (ω-OHFAs) are multifunctional compounds that act
as the basis for the production of various industrial products with broad commercial and …

Regiospecific modifications of naringenin for astragalin production in Escherichia coli

S Malla, RP Pandey, BG Kim… - Biotechnology and …, 2013 - Wiley Online Library
We report the production of astragalin (AST) from regiospecific modifications of naringenin (NRN)
in Escherichia coli BL21(DE3). The exogenously supplied NRN was converted into …

[HTML][HTML] Self-resistance mechanism in Streptomyces peucetius: overexpression of drrA, drrB and drrC for doxorubicin enhancement

S Malla, NP Niraula, K Liou, JK Sohng - Microbiological research, 2010 - Elsevier
The resistance genes drrABC from Streptomyces peucetius ATCC 27952 were cloned into
the pIBR25 expression vector under a strong ermE* promoter to enhance doxorubicin (DXR) …

Endothelial cell activation in patients with decompensated heart failure

…, JE Banchs, S Celaj, A Talreja, J Lachmann, S Malla… - Circulation, 2005 - Am Heart Assoc
Background— Vascular endothelial functions, other than nitric oxide (NO)–mediated control
of vasomotor tone, are poorly characterized in patients with chronic heart failure (CHF). …