Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic
complications. Through trans-ancestry meta-analysis of genome-wide association studies of …

We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls
of diverse ancestry, identifying 40 coding variant association signals (P < 2.2 × 10 −7 ); of …

Background Glycated hemoglobin (HbA1c) is used to diagnose type 2 diabetes (T2D) and
assess glycemic control in patients with diabetes. Previous genome-wide association studies (…

Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via poorly
understood mechanisms. We performed a trans-ancestry genome-wide association study …

Few genome-wide association studies (GWAS) account for environmental exposures, like
smoking, potentially impacting the overall trait variance when investigating the genetic …

Genome-wide association analysis advanced understanding of blood pressure (BP), a major
risk factor for vascular conditions such as coronary heart disease and stroke. Accounting …

The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are
influenced by smoking, but it is unknown whether genetic associations with lipids may be …

Smoking is a major heritable and modifiable risk factor for many diseases, including cancer,
common respiratory disorders and cardiovascular diseases. Fourteen genetic loci have …

A person’s lipid profile is influenced by genetic variants and alcohol consumption, but the
contribution of interactions between these exposures has not been studied. We therefore …

Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by
which alcohol consumption impact blood pressure (BP) regulation remains unknown. We …