Apicomplexan parasites are leading causes of human and livestock diseases such as malaria
and toxoplasmosis, yet most of their genes remain uncharacterized. Here, we present the …

Vaccines have had broad medical impact, but existing vaccine technologies and production
methods are limited in their ability to respond rapidly to evolving and emerging pathogens, …

Toxoplasma gondii is a parasite of humans and animals, and a model for other apicomplexans
including Plasmodium spp., the causative agents of malaria. Despite many advances, …

Toxoplasma gondii is a protozoan pathogen in the phylum Apicomplexa that resides within
an intracellular parasitophorous vacuole (PV) that is selectively permeable to small …

Toxoplasma can reach distant organs, especially the brain, leading to a lifelong chronic
phase. However, genes involved in related in vivo processes are currently unknown. Here, we …

Apicomplexan parasites, such as Toxoplasma gondii, cause extensive morbidity and
mortality in humans and livestock, highlighting the need for a deeper understanding of their …

The life cycles of apicomplexan parasites progress in accordance with fluxes in cytosolic Ca
2+ . Such fluxes are necessary for events like motility and egress from host cells. We used …

Artemisinins have revolutionized the treatment of Plasmodium falciparum malaria; however,
resistance threatens to undermine global control efforts. To broadly explore artemisinin …

Apicomplexan parasites include the causative agents of malaria and toxoplasmosis. Cell-based
screens in Toxoplasma previously identified a chemical modulator of calcium signaling (…

Shigellosis is a severe diarrheal disease that affects hundreds of thousands of individuals
resulting in significant morbidity and mortality worldwide. Shigellosis is caused by Shigella spp…