Preexisting and de novo humoral immunity to SARS-CoV-2 in humans

…, GH Cornish, A Rosa, R Harvey, S Hussain… - Science, 2020 - science.org
Zoonotic introduction of novel coronaviruses may encounter preexisting immunity in humans.
Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, we detected …

Neutralising antibody activity against SARS-CoV-2 VOCs B. 1.617. 2 and B. 1.351 by BNT162b2 vaccination

…, R Daniels, P Hobson, E Hatipoglu, Y Ngai, S Hussain… - The Lancet, 2021 - thelancet.com
that emerged in the UK with the second COVID-19 wave in late 2020. The efficacy of currently
licensed COVID-19 vaccines against B. 1.617. 2 is unknown; although it possesses 12 …

[HTML][HTML] A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising …

…, AH Keeble, L Schimanski, S Hussain… - Nature …, 2021 - nature.com
There is need for effective and affordable vaccines against SARS-CoV-2 to tackle the
ongoing pandemic. In this study, we describe a protein nanoparticle vaccine against SARS-CoV-2. …

SARS-CoV-2 S2–targeted vaccination elicits broadly neutralizing antibodies

…, K Finsterbusch, M Wu, R Harvey, S Hussain… - Science translational …, 2022 - science.org
Several variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have
emerged during the current coronavirus disease 2019 (COVID-19) pandemic. Although …

[HTML][HTML] AZD1222-induced neutralising antibody activity against SARS-CoV-2 Delta VOC

…, L Adams, P Hobson, E Hatipoglu, Y Ngai, S Hussain… - The Lancet, 2021 - thelancet.com
The SARS-CoV-2 B. 1.617. 2 Delta variant of concern (VOC) continues to drive a sharp increase
in COVID-19 cases in the UK, with a current doubling time of 3· 5–16 days, 1 consistent …

Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients

EJ Carr, M Wu, R Harvey, EC Wall, G Kelly, S Hussain… - The Lancet, 2021 - thelancet.com
We sought to compare neutralising antibody responses between seronaive haemodialysis
patients and the healthy individuals we have already reported on as part of the Legacy study. …

[HTML][HTML] Evolution of the SARS-CoV-2 spike protein in the human host

…, DJ Benton, C Roustan, A Borg, S Hussain… - Nature …, 2022 - nature.com
Recently emerged variants of SARS-CoV-2 contain in their surface spike glycoproteins
multiple substitutions associated with increased transmission and resistance to neutralising …

[HTML][HTML] Breadth and function of antibody response to acute SARS-CoV-2 infection in humans

…, TH Chen, CG Huang, R Harvey, S Hussain… - Plos …, 2021 - journals.plos.org
Serological and plasmablast responses and plasmablast-derived IgG monoclonal antibodies
(MAbs) have been analysed in three COVID-19 patients with different clinical severities. …

Reduced antibody cross-reactivity following infection with B. 1.1. 7 than with parental SARS-CoV-2 strains

…, S Paraskevopoulou, C Houlihan, S Hussain… - Elife, 2021 - elifesciences.org
Background: The degree of heterotypic immunity induced by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) strains is a major determinant of the spread of emerging …

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase

…, R Ulferts, M Wu, R Harvey, S Hussain… - Biochemical …, 2021 - portlandpress.com
The coronavirus disease 2019 (COVID-19) pandemic, which is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global public health challenge. While …