Preexisting and de novo humoral immunity to SARS-CoV-2 in humans
…, GH Cornish, A Rosa, R Harvey, S Hussain… - Science, 2020 - science.org
Zoonotic introduction of novel coronaviruses may encounter preexisting immunity in humans.
Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, we detected …
Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, we detected …
Neutralising antibody activity against SARS-CoV-2 VOCs B. 1.617. 2 and B. 1.351 by BNT162b2 vaccination
…, R Daniels, P Hobson, E Hatipoglu, Y Ngai, S Hussain… - The Lancet, 2021 - thelancet.com
that emerged in the UK with the second COVID-19 wave in late 2020. The efficacy of currently
licensed COVID-19 vaccines against B. 1.617. 2 is unknown; although it possesses 12 …
licensed COVID-19 vaccines against B. 1.617. 2 is unknown; although it possesses 12 …
[HTML][HTML] A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising …
…, AH Keeble, L Schimanski, S Hussain… - Nature …, 2021 - nature.com
There is need for effective and affordable vaccines against SARS-CoV-2 to tackle the
ongoing pandemic. In this study, we describe a protein nanoparticle vaccine against SARS-CoV-2. …
ongoing pandemic. In this study, we describe a protein nanoparticle vaccine against SARS-CoV-2. …
SARS-CoV-2 S2–targeted vaccination elicits broadly neutralizing antibodies
…, K Finsterbusch, M Wu, R Harvey, S Hussain… - Science translational …, 2022 - science.org
Several variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have
emerged during the current coronavirus disease 2019 (COVID-19) pandemic. Although …
emerged during the current coronavirus disease 2019 (COVID-19) pandemic. Although …
[HTML][HTML] AZD1222-induced neutralising antibody activity against SARS-CoV-2 Delta VOC
…, L Adams, P Hobson, E Hatipoglu, Y Ngai, S Hussain… - The Lancet, 2021 - thelancet.com
The SARS-CoV-2 B. 1.617. 2 Delta variant of concern (VOC) continues to drive a sharp increase
in COVID-19 cases in the UK, with a current doubling time of 3· 5–16 days, 1 consistent …
in COVID-19 cases in the UK, with a current doubling time of 3· 5–16 days, 1 consistent …
Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients
We sought to compare neutralising antibody responses between seronaive haemodialysis
patients and the healthy individuals we have already reported on as part of the Legacy study. …
patients and the healthy individuals we have already reported on as part of the Legacy study. …
[HTML][HTML] Evolution of the SARS-CoV-2 spike protein in the human host
…, DJ Benton, C Roustan, A Borg, S Hussain… - Nature …, 2022 - nature.com
Recently emerged variants of SARS-CoV-2 contain in their surface spike glycoproteins
multiple substitutions associated with increased transmission and resistance to neutralising …
multiple substitutions associated with increased transmission and resistance to neutralising …
[HTML][HTML] Breadth and function of antibody response to acute SARS-CoV-2 infection in humans
…, TH Chen, CG Huang, R Harvey, S Hussain… - Plos …, 2021 - journals.plos.org
Serological and plasmablast responses and plasmablast-derived IgG monoclonal antibodies
(MAbs) have been analysed in three COVID-19 patients with different clinical severities. …
(MAbs) have been analysed in three COVID-19 patients with different clinical severities. …
Reduced antibody cross-reactivity following infection with B. 1.1. 7 than with parental SARS-CoV-2 strains
…, S Paraskevopoulou, C Houlihan, S Hussain… - Elife, 2021 - elifesciences.org
Background: The degree of heterotypic immunity induced by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) strains is a major determinant of the spread of emerging …
coronavirus 2 (SARS-CoV-2) strains is a major determinant of the spread of emerging …
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase
…, R Ulferts, M Wu, R Harvey, S Hussain… - Biochemical …, 2021 - portlandpress.com
The coronavirus disease 2019 (COVID-19) pandemic, which is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global public health challenge. While …
respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global public health challenge. While …