The hierarchical relationships between various stem and progenitor cell subpopulations
driving mammary gland morphogenesis and homoeostasis are poorly understood. Conditional …

Oriented cell divisions are critical for the formation and maintenance of structured epithelia.
Proper mitotic spindle orientation relies on polarised anchoring of force generators to the cell …

Little is known about the mechanisms of mitotic spindle orientation during mammary gland
morphogenesis. Here, we report the presence of huntingtin, the protein mutated in …

The transcriptional repressor Blimp-1 originally cloned as a silencer of type I interferon (IFN)-β
gene expression controls cell fate decisions in multiple tissue contexts. Conditional …

The enduring lack of diversity, equity and inclusion (DEI) in academia is arguably the biggest
challenge facing universities. Progress has been slow and dependent on the efforts of …

A polyglutamine expansion in huntingtin (HTT) causes the specific death of adult neurons in
Huntington's disease (HD). Most studies have thus focused on mutant HTT (mHTT) toxicity …

Chromogranin A (CgA) has been proposed to play a major role in the formation of dense-core
secretory granules (DCGs) in neuroendocrine cells. Here, we took advantage of unique …

Selenoproteins contain the essential trace element selenium whose deficiency leads to
major disorders including cancer, male reproductive system failure, or autoimmune thyroid …

Conferences are often held at different venues and feature innovative scientific programs;
however, their design rarely changes, and barriers that exclude marginalized scientists persist. …

The establishment of apical-basolateral polarity is important for both normal development
and disease, for example, during tumorigenesis and metastasis. During this process, polarity …