… name, which should have been spelled Salah-Eddine Lamhamedi-Cherradi. This mistake
has been corrected in the HTML version and print versions of the article. We regret the error. …

The pronounced biological influence of the tumor microenvironment on cancer progression
and metastasis has gained increased recognition over the past decade, yet most preclinical …

JCI - Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation Go
to JCI Insight About Editors Consulting Editors For authors Publication ethics Alerts …

The tumor suppressor p53 regulates apoptosis, cell cycle, and oncogenesis. To explore the
roles of p53 in autoimmunity, we studied type 1 diabetes and innate immune responses …

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) selectively induces
apoptosis of tumor cells but not most normal cells. Its roles in normal nontransformed tissues …

Three-dimensional tumor models accurately describe different aspects of the tumor
microenvironment and are readily available for mechanistic studies of tumor biology and for drug …

Purpose: Desmoplastic small round cell tumor (DSRCT), which harbors EWSR1-WT1 t(11;22)(p13:q12)
chromosomal translocation, is an aggressive malignancy that typically presents …

Abstract Development of type I diabetes requires coordinated expression of myriad genes
responsible for the initiation and progression of the disease. Expression of these genes are …

Background: Therapies cotargeting insulin-like growth factor receptor 1 (IGF-1R) and mammalian
target of rapamycin (mTOR) have demonstrated remarkable, albeit short-lived, clinical …

Long-term display of exogenous proteins on the cell surface may have important research
and therapeutic implications. We report a novel method for the cell-surface display of proteins …