The myelin sheath is a multilayered membrane in the nervous system, which has unique
biochemical properties. Myelin carries a set of specific high‐abundance proteins, the structure …

A link between sites of cell adhesion and the cytoskeleton is essential for regulation of cell
shape, motility, and signaling. Migfilin is a recently identified adaptor protein that localizes at …

Compact myelin comprises most of the dry weight of myelin, and its insulative nature is the
basis for saltatory conduction of nerve impulses. The major dense line (MDL) is a 3-nm …

Peripheral myelin protein 2 (Pmp2, P2 or Fabp8), a member of the fatty acid binding protein
family, was originally described together with myelin basic protein (Mbp or P1) and myelin …

Compact myelin forms the basis of nerve insulation essential for higher vertebrates. Dozens
of myelin membrane bilayers undergo tight stacking, and in the peripheral nervous system, …

Filamins are actin filament cross-linking proteins composed of an N-terminal actin-binding
domain and 24 immunoglobulin-like domains (IgFLNs). Filamins interact with numerous …

The myelin sheath is an essential, multilayered membrane structure that insulates axons,
enabling the rapid transmission of nerve impulses. The tetraspan myelin proteolipid protein (…

P2 is a fatty acid-binding protein expressed in vertebrate peripheral nerve myelin, where it
may function in bilayer stacking and lipid transport. P2 binds to phospholipid membranes …

Charcot-Marie-Tooth (CMT) disease is one of the most common inherited neuropathies.
Recently, three CMT1-associated point mutations (I43N, T51P, and I52T) were discovered in the …

Filamins are large proteins that cross-link actin filaments and connect to other cellular
components. The C-terminal rod 2 region of FLNa (filamin A) mediates dimerization and interacts …