Original research: Targeting PARP-1 with metronomic therapy modulates MDSC suppressive
function and enhances anti-PD-1 immunotherapy in colon cancer - PMC Back to Top Skip …

Nitazoxanide (Alinia ® , NTZ) and tizoxanide (TIZ), its active circulating metabolite, belong
to a class of agents known as thiazolides (TZD) endowed with broad anti-infective activities. …

Background An important portion of asthmatics do not respond to current therapies. Thus, the
need for new therapeutic drugs is urgent. We have demonstrated a critical role for PARP in …

Background Increasing evidence has shown the close link between energy metabolism and
the differentiation, function, and longevity of immune cells. Chronic inflammatory conditions …

Our laboratory established a role for poly(ADP-ribose)polymerase (PARP) in asthma. To
increase the clinical significance of our studies, it is imperative to demonstrate that PARP is …

Background: Haplotype-specific alternative splicing of the endoplasmic reticulum (ER)
aminopeptidase type 2 (ERAP2) gene results in either full-length (FL, haplotype A) or alternatively …

Background: Interleukin-21 (IL-21) modulates HIV-1 infection through the elicitation of different
antiviral mechanisms, including Th17 lineage commitment and induction of microRNA (…

A critical feature of cancer is the ability to induce immunosuppression and evade immune
responses. Tumor-induced immunosuppression diminishes the effectiveness of endogenous …

Background: 25-hydroxylase (CH25H) is an interferon-stimulated gene (ISG), which
catalyzes the synthesis of 25-hydroxycholesterol (25HC). 25HC intervenes in metabolic and …

Background The efficacy of heparins and low-MW-heparins (LMWH) against human asthma
has been known for decades. However, the clinical utility of these compounds has been …