BACKGROUND ‘Omics’ high-throughput analyses, including genomics, epigenomics,
transcriptomics, proteomics and metabolomics, are widely applied in human endometrial studies. …

This review summarizes current knowledge of the effect of folate-mediated one-carbon
metabolism and related genetic variants on female fertility and pregnancy viability. Insufficient …

Primary ovarian insufficiency (POI) affects ∼1% of women before 40 years of age. The recent
leap in genetic knowledge obtained by next generation sequencing (NGS) together with …

Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory
arthritis. By combining data from >140,000 individuals of European ancestry within the Global …

Endometriosis is a common condition associated with debilitating pelvic pain and infertility.
A genome-wide association study meta-analysis, including 60,674 cases and 701,926 …

Polycystic ovary syndrome (PCOS) is a disorder characterized by hyperandrogenism,
ovulatory dysfunction and polycystic ovarian morphology. Affected women frequently have …

Background DNA epigenetic modifications, such as methylation, are important regulators of
tissue differentiation, contributing to processes of both development and cancer. Profiling the …

Anaemia is a chief determinant of global ill health, contributing to cognitive impairment,
growth retardation and impaired physical capacity. To understand further the genetic factors …

To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22
genome-wide association studies (GWAS) in 38,968 women of European descent, with …

The application of high-throughput sequencing methods has raised doubt in the concept of
the uniform healthy vaginal microbiota consisting predominantly of lactobacilli by revealing …