We conducted a case-control study of 116 patients with the clinical diagnosis of Alzheimer's
disease (AD) in seven Italian centers. One hundred sixteen hospital controls and 97 …

Introduction of novel and diverse functional groups in drug discovery is always seen with
hesitancy until good activity and low toxicity characteristics are proven. The introduction of …

Dengue virus (DENV) has emerged as major human pathogen. Despite the serious socio-economic
impact of DENV-associated diseases, antiviral therapy is missing. DENV replicates …

Prostate cancer (PC) is one of the major causes of male death worldwide and the development
of new and more potent anti-PC compounds is a constant requirement. Among the …

The antihypertensive flavonol quercetin (Q1) is endowed with a cardioprotective effect
against myocardial ischemic damage. Q1 inhibits angiotensin converting enzyme activity, …

Blood coagulation functions as part of the innate immune system by preventing bacterial
invasion, and it is critical to stopping blood loss (hemostasis). Coagulation involves the external …

We recently identified indole derivatives (IIIe and IIIf) with anti-chikungunya virus (CHIKV)
activities at lower micro molar concentrations and a selective index of inhibition higher than the …

The clinical evidence for the success of tyrosine kinase inhibitors in combination with
microtubule-targeting agents prompted us to design and develop single agents that possess both …

Schistosomiasis endangers the lives of greater than 200 million people every year and is
predominantly controlled by a single class chemotherapy, praziquantel (PZQ). Development of …

The biocatalytic aromatization of indolines into indole derivatives exploiting monoamine
oxidase (MAO-N) enzymes is presented. Indoline substrates were prepared via photocatalytic …