Regenerative medicine is a branch of translational research that aims to reestablish irreparably
damaged tissues and organs by stimulating the body’s own repair mechanisms via the …

One of the most powerful ways to test the function of a protein is to characterize the consequences
of its deletion. In the past, this has involved inactivation of the gene by homologous …

CaMKII is one of the most studied synaptic proteins, but many critical issues regarding its
role in synaptic function remain unresolved. Using a CRISPR-based system to delete CaMKII …

Phosphorylation regulates surface and synaptic expression of NMDA receptors (NMDARs).
Both the tyrosine kinase Fyn and the tyrosine phosphatase striatal-enriched protein tyrosine …

We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is
required for LTP. We found that a knock-in mouse lacking the CTD of GluA1 expresses normal …

The mechanisms by which natural rewards such as sugar affect synaptic transmission and
behavior are largely unexplored. Here, we investigate regulation of nucleus accumbens …

Striatal-enriched protein tyrosine phosphatase (STEP) is a brain-specific protein phosphatase
that regulates a variety of synaptic proteins, including NMDA receptors (NAMDRs). To …

Brain oscillations have long-lasting effects on synaptic and cellular properties. For instance,
synaptic stimulation at theta (θ) frequency induces persistent depression of both excitatory …

KCNQ-Kv7 channels are found at the axon initial segment of pyramidal neurons, where they
control cell firing and membrane potential. In oriens lacunosum moleculare (O-LM) …

Neurodevelopmental disorders are frequently linked to mutations in synaptic organizing
molecules. MAM domain containing glycosylphosphatidylinositol anchor 1 and 2 (MDGA1 and …