Machine learning prediction of resistance to subinhibitory antimicrobial concentrations from Escherichia coli genomes
S Benkwitz-Bedford, M Palm, TY Demirtas… - Msystems, 2021 - Am Soc Microbiol
Escherichia coli is an important cause of bacterial infections worldwide, with multidrug-resistant
strains incurring substantial costs on human lives. Besides therapeutic concentrations of …
strains incurring substantial costs on human lives. Besides therapeutic concentrations of …
Allele-Specific Expression of Leukemia Genes Is Associated with Pathogenicity in Poor Risk AML
…, M Guscott, S Krizsán, S Benkwitz-Bedford… - Blood, 2023 - Elsevier
Introduction: An imbalance in gene expression of the different alleles of a gene (allele-specific
expression or ASE) is an intriguing genome-wide and dynamic phenomenon that could …
expression or ASE) is an intriguing genome-wide and dynamic phenomenon that could …
Deep Multi-Omics Profiling in Cytogenetically Poor-Risk AML
…, S Krizsán, C Middleton, S Benkwitz-Bedford… - Blood, 2022 - ashpublications.org
Introduction: Acute myeloid leukemia (AML) patients with adverse cytogenetics have particularly
poor outcomes with median survival of only 7.6 months. The treatment of these patients …
poor outcomes with median survival of only 7.6 months. The treatment of these patients …
A agent based modelling framework for dynamic biological systems and applications to cancer cells, G protein coupled receptors and G proteins
SRE Benkwitz-Bedford - 2022 - etheses.bham.ac.uk
Dynamic real-world biological systems are quite difficult to study because it requires us to
understand the interactions within, without being able to isolate them. This hidden complexity …
understand the interactions within, without being able to isolate them. This hidden complexity …
Targeting AKT/mTOR pathway in order to sensitise rectal tumour cells to irradiation using patient derived organoids as a model
AA Stodolna - 2022 - etheses.bham.ac.uk
Treatment resistance is one of the key contributors to low overall survival rates in Colorectal
cancer (CRC) patients. Although both resistance to chemotherapy and radiotherapy is …
cancer (CRC) patients. Although both resistance to chemotherapy and radiotherapy is …
Understanding the metabolic signatures of haematological cancers through an integrative multi-Omics approach
G Papatzikas - 2022 - etheses.bham.ac.uk
… Additionally, I would like to thank Ms Nuria Vilaplana, Ms Zuhal Eraslan, Ms Agata Stodolna
and Mr Sam Benkwitz-Bedford for providing data and working together in various projects; to …
and Mr Sam Benkwitz-Bedford for providing data and working together in various projects; to …