User profiles for Sam Michael

Michael Sam

University of Otago
Verified email at otago.ac.nz
Cited by 1778

The National COVID Cohort Collaborative (N3C): rationale, design, infrastructure, and deployment

…, N Qureshi, MG Kurilla, SG Michael… - Journal of the …, 2021 - academic.oup.com
Objective Coronavirus disease 2019 (COVID-19) poses societal challenges that require
expeditious data and knowledge sharing. Though organizational clinical data are abundant, …

Security analysis of integrated circuit camouflaging

J Rajendran, M Sam, O Sinanoglu, R Karri - Proceedings of the 2013 …, 2013 - dl.acm.org
Camouflaging is a layout-level technique that hampers an attacker from reverse engineering
by introducing, in one embodiment, dummy contacts into the layout. By using a mix of real …

High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell–like diffuse large B-cell lymphoma cells

…, DY Duveau, JK Jiang, S Michael… - Proceedings of the …, 2014 - National Acad Sciences
The clinical development of drug combinations is typically achieved through trial-and-error
or via insight gained through a detailed molecular understanding of dysregulated signaling …

Undiagnosed SARS-CoV-2 seropositivity during the first 6 months of the COVID-19 pandemic in the United States

…, JP Denson, S Messing, SG Michael… - Science Translational …, 2021 - science.org
Asymptomatic SARS-CoV-2 infection and delayed implementation of diagnostics have led
to poorly defined viral prevalence rates in the United States and elsewhere. To address this, …

[PDF][PDF] Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress

…, L Chen, J Travers, C McKnight, S Michael… - Cancer Cell, 2021 - cell.com
Small cell neuroendocrine cancers (SCNCs) are recalcitrant cancers arising from diverse
primary sites that lack effective treatments. Using chemical genetic screens, we identified …

The Tox21 robotic platform for the assessment of environmental chemicals–from vision to reality

MS Attene-Ramos, N Miller, R Huang, S Michael… - Drug discovery today, 2013 - Elsevier
Highlights • The Tox21 effort is to advance in vitro toxicological testing in the 21st century. •
Tox21 chemical library contains approximately 10,000 environmental chemicals. • A battery …

[HTML][HTML] Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition

…, C Lowe, D Matak-Vinković, S Michael… - Nature …, 2014 - nature.com
The transcription factor FOXM1 binds to sequence-specific motifs on DNA (C/TAAACA)
through its DNA-binding domain (DBD) and activates proliferation- and differentiation-associated …

The public management of sport: Wicked problems, challenges and dilemmas

MP Sam - Public management review, 2009 - Taylor & Francis
This article proposes that sport policy problems exhibit the characteristics of ‘wicked problems’,
in that they are difficult to define/interpret, are based in competing/uncertain causes, and …

[HTML][HTML] Standardization of ELISA protocols for serosurveys of the SARS-CoV-2 pandemic using clinical and at-home blood sampling

…, G Gulten, S Messing, J Hicks, S Michael… - Nature …, 2021 - nature.com
The extent of SARS-CoV-2 infection throughout the United States population is currently
unknown. High quality serology is key to avoiding medically costly diagnostic errors, as well as …

A robotic platform for quantitative high-throughput screening

S Michael, D Auld, C Klumpp, A Jadhav… - Assay and drug …, 2008 - liebertpub.com
High-throughput screening (HTS) is increasingly being adopted in academic institutions,
where the decoupling of screening and drug development has led to unique challenges, as …