Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints
…, J Le, J O'Moore, R Pitstick, S Graffam… - Nucleic acids …, 2020 - academic.oup.com
Lowering of prion protein (PrP) expression in the brain is a genetically validated therapeutic
hypothesis in prion disease. We recently showed that antisense oligonucleotide (ASO)-…
hypothesis in prion disease. We recently showed that antisense oligonucleotide (ASO)-…
[HTML][HTML] Antisense oligonucleotides extend survival of prion-infected mice
…, LD Raymond, K Williams, EE Swayze, S Graffam… - JCI insight, 2019 - ncbi.nlm.nih.gov
Prion disease is a fatal, incurable neurodegenerative disease of humans and other mammals
caused by conversion of cellular prion protein (PrP C) into a self-propagating neurotoxic …
caused by conversion of cellular prion protein (PrP C) into a self-propagating neurotoxic …
Active learning in medical education: strategies for beginning implementation
B Graffam - Medical teacher, 2007 - Taylor & Francis
… Again, the student is selected before the question is asked: ‘Samantha, what did you think
of John's idea that pink eye is the most diagnosed condition?’ Samantha can now answer in …
of John's idea that pink eye is the most diagnosed condition?’ Samantha can now answer in …
[HTML][HTML] Removing 80%–90% of nitrogen and organic contaminants with three distinct passive, lignocellulose-based on-site septic systems receiving municipal and …
…, S Waugh, C Asato, PM Clyde, SC Nyer, M Graffam… - Ecological …, 2021 - Elsevier
Three distinct septic systems designed for onsite removal of nitrogen (N) from residential
wastewater were installed at the Massachusetts Alternative Septic System Test Center (…
wastewater were installed at the Massachusetts Alternative Septic System Test Center (…
Nitrogen transformations in constructed wetlands: A closer look at plant-soil interactions using chemical imaging
SC Nyer, N Volkenborn, RC Aller, M Graffam… - Science of The Total …, 2022 - Elsevier
Constructed wetlands have long been used for domestic wastewater treatment. Despite the
widespread application of constructed wetlands for wastewater remediation, they are still …
widespread application of constructed wetlands for wastewater remediation, they are still …
Gut microbiome perturbations induced by bacterial infection affect arsenic biotransformation
…, PH Cable, RP Abo, H Ru, ME Graffam… - Chemical research in …, 2013 - ACS Publications
Exposure to arsenic affects large human populations worldwide and has been associated
with a long list of human diseases, including skin, bladder, lung, and liver cancers, diabetes, …
with a long list of human diseases, including skin, bladder, lung, and liver cancers, diabetes, …
Employer satisfaction with employees with a disability: Comparisons with other employees
K Smith, L Webber, J Graffam… - Journal of Vocational …, 2004 - content.iospress.com
This paper is based on survey responses from 656 employers who had employed someone
with a disability using support from disability employment agencies. Differences in employers…
with a disability using support from disability employment agencies. Differences in employers…
Conditioning of nyala (Tragelaphus angasi) to blood sampling in a crate with positive reinforcement
…, M Phillips, RC Cambre, NA Irlbeck, W Graffam - 1995 - Wiley Online Library
Habituation and positive reinforcement procedures were successfully used for low stress
blood sampling of nyala (Tragelaphus angasi) at the Denver Zoological Gardens. Four adult …
blood sampling of nyala (Tragelaphus angasi) at the Denver Zoological Gardens. Four adult …
Ancient metallurgy in the Atacama: evidence for copper smelting during Chile's Early Ceramic Period
G Graffam, M Rivera, Á Carevič - Latin american antiquity, 1996 - cambridge.org
Investigations at the Ramaditas site (Guatacondo Valley, northern Chile) were successful in
the discovery of small quantities of ancient metallurgical slag, copper ore, and metal from …
the discovery of small quantities of ancient metallurgical slag, copper ore, and metal from …
[HTML][HTML] Humor in workplace leadership: A systematic search scoping review
Humor studies are increasingly prevalent in workplace and leadership domains, it has
shown significant development in the last 40 years. The multifaceted nature of humor means …
shown significant development in the last 40 years. The multifaceted nature of humor means …