User profiles for Samantha L. Payne

Samantha Payne

Assistant Professor, University of Guelph
Verified email at uoguelph.ca
Cited by 810

The anatomy and histology of caudal autotomy and regeneration in lizards

EAB Gilbert, SL Payne… - Physiological and …, 2013 - journals.uchicago.edu
Caudal autotomy—the ability to self-detach the tail—is a dramatic adaptation common to
many structural-grade lizards. For most species, tail loss is followed by the equally dramatic …

[HTML][HTML] Potassium channel-driven bioelectric signalling regulates metastasis in triple-negative breast cancer

SL Payne, P Ram, DH Srinivasan, TT Le, M Levin… - …, 2022 - thelancet.com
Background There is a critical need to better understand the mechanisms that drive local
cell invasion and metastasis to develop new therapeutics targeting metastatic disease. …

Combined delivery of chondroitinase ABC and human induced pluripotent stem cell-derived neuroepithelial cells promote tissue repair in an animal model of spinal …

T Führmann, PN Anandakumaran, SL Payne… - Biomedical …, 2018 - iopscience.iop.org
The lack of tissue regeneration after traumatic spinal cord injury in animal models is largely
attributed to the local inhibitory microenvironment. To overcome this inhibitory environment …

Injectable hydrogel enables local and sustained co-delivery to the brain: two clinically approved biomolecules, cyclosporine and erythropoietin, accelerate functional …

A Tuladhar, JM Obermeyer, SL Payne, RCW Siu… - Biomaterials, 2020 - Elsevier
Therapeutic delivery to the brain is limited by the blood-brain barrier and is exacerbated by
off-target effects associated with systemic delivery, thereby precluding many potential …

Bioelectric control of metastasis in solid tumors

SL Payne, M Levin, MJ Oudin - Bioelectricity, 2019 - liebertpub.com
As the leading cause of death in cancer, there is an urgent need to develop treatments to
target the dissemination of primary tumor cells to secondary organs, known as metastasis. …

[HTML][HTML] Beyond neurons: long distance communication in development and cancer

…, MJ Oudin, M Levin, SL Payne - Frontiers in Cell and …, 2021 - frontiersin.org
Cellular communication is important in all aspects of tissue and organism functioning, from
the level of single cells, two discreet populations, and distant tissues of the body. Long …

Biomaterial-based cell delivery strategies to promote liver regeneration

M Ali, SL Payne - Biomaterials Research, 2021 - spj.science.org
Chronic liver disease and cirrhosis is a widespread and untreatable condition that leads to
lifelong impairment and eventual death. The scarcity of liver transplantation options requires …

Local delivery of stabilized chondroitinase ABC degrades chondroitin sulfate proteoglycans in stroke-injured rat brains

MH Hettiaratchi, MJ O'Meara, CJ Teal, SL Payne… - Journal of controlled …, 2019 - Elsevier
Central nervous system (CNS) injuries, such as stroke and spinal cord injuries, result in the
formation of a proteoglycan-rich glial scar, which acts as a barrier to axonal regrowth and …

Local delivery of brain-derived neurotrophic factor enables behavioral recovery and tissue repair in stroke-injured rats

JM Obermeyer, A Tuladhar, SL Payne, E Ho… - … Engineering Part A, 2019 - liebertpub.com
We induced tissue repair following ischemic stroke in rats by delivering brain-derived
neurotrophic factor (BDNF) directly to the brain. This protein is a potent modulator of plasticity and …

Initial cell maturity changes following transplantation in a hyaluronan-based hydrogel and impacts therapeutic success in the stroke-injured rodent brain

SL Payne, A Tuladhar, JM Obermeyer, BV Varga… - Biomaterials, 2019 - Elsevier
Ischemic stroke results in a loss of neurons for which there are no available clinical strategies
to stimulate regeneration. While preclinical studies have demonstrated that functional …