Optimization of AsCas12a for combinatorial genetic screens in human cells
…, MN Feeley, AL Griffith, T Teng, SM Borys… - Nature …, 2021 - nature.com
Cas12a RNA-guided endonucleases are promising tools for multiplexed genetic perturbations
because they can process multiple guide RNAs expressed as a single transcript, and …
because they can process multiple guide RNAs expressed as a single transcript, and …
[HTML][HTML] The yin and yang of targeting KLRG1+ Tregs and effector cells
SM Borys, AK Bag, L Brossay, DO Adeegbe - Frontiers in Immunology, 2022 - frontiersin.org
The literature surrounding KLRG1 has primarily focused on NK and CD8 + T cells. However,
there is evidence that the most suppressive Tregs express KLRG1. Until now, the role of …
there is evidence that the most suppressive Tregs express KLRG1. Until now, the role of …
[HTML][HTML] Identification of functional regulatory elements in the human genome using pooled CRISPR screens
SM Borys, ST Younger - BMC genomics, 2020 - Springer
Background Genome-scale pooled CRISPR screens are powerful tools for identifying genetic
dependencies across varied cellular processes. The vast majority of CRISPR screens …
dependencies across varied cellular processes. The vast majority of CRISPR screens …
Optimization of AsCas12a for combinatorial genetic screens in human cells
…, AK Sangree, RE Hanna, M Hegde, T Teng, SM Borys… - BioRxiv, 2019 - biorxiv.org
Cas12a enzymes have attractive properties for scalable delivery of multiplexed perturbations,
yet widespread usage has lagged behind Cas9-based strategies. Here we describe the …
yet widespread usage has lagged behind Cas9-based strategies. Here we describe the …
PD-1 Mediated Regulation of Unique Activated CD8+ T Cells by NK Cells in the Submandibular Gland
L Brossay, SM Borys, SP Reilly, I Magill, D Zemmour - bioRxiv, 2023 - biorxiv.org
The increasing utilization of anti-PD-1 immune checkpoint blockade (ICB) has led to the
emergence of immune-related adverse events (irAEs), including sicca syndrome. Interestingly, …
emergence of immune-related adverse events (irAEs), including sicca syndrome. Interestingly, …
PD-1 Mediated Regulation of Unique Activated CD8+ T Cells by NK Cells in the Submandibular Gland
SM Borys, SP Reilly, I Magill, D Zemmour, L Brossay - bioRxiv, 2023 - ncbi.nlm.nih.gov
The increasing utilization of anti-PD-1 immune checkpoint blockade (ICB) has led to the
emergence of immune-related adverse events (irAEs), including sicca syndrome. Interestingly, …
emergence of immune-related adverse events (irAEs), including sicca syndrome. Interestingly, …
Post-anaesthesia pulmonary complications after use of muscle relaxants (POPULAR): a multicentre, prospective observational study
…, K Borstnar, M Borys… - The Lancet …, 2019 - thelancet.com
Background Results from retrospective studies suggest that use of neuromuscular blocking
agents during general anaesthesia might be linked to postoperative pulmonary complications…
agents during general anaesthesia might be linked to postoperative pulmonary complications…
[HTML][HTML] SHP-2 deletion in CD4Cre expressing chondrocyte precursors leads to tumor development with wrist tropism
JT McNamara, KE Huntington, S Borys… - Scientific Reports, 2021 - nature.com
Due to redundancy with other tyrosine phosphatases, the ubiquitously expressed tyrosine
phosphatase SHP-2 (encoded by Ptpn11) is not required for T cell development. However, …
phosphatase SHP-2 (encoded by Ptpn11) is not required for T cell development. However, …
SHP-2 deletion in CD4+ chondrocyte precursors leads to tumor development with wrist tropism
L Brossay, J McNamara, K Huntington, S Borys… - 2021 - researchsquare.com
Due to redundancy with other tyrosine phosphatases, the ubiquitously expressed tyrosine
phosphatase SHP-2 (encoded by Ptpn11) is not required for T cell development. However, …
phosphatase SHP-2 (encoded by Ptpn11) is not required for T cell development. However, …
[BOOK][B] Radiology and Pathology Correlation of Bone Tumors, None: A Quick Reference and Review
A Greenspan, D Borys - 2015 - books.google.com
… the Department of Radiology, University of California, Davis Medical Center in Sacramento,
California, for creating some of the digital images, and to Michael Greenspan and Samantha …
California, for creating some of the digital images, and to Michael Greenspan and Samantha …