User profiles for Sameed Ahmed

Sameed Ahmed

Quantitative Scientist, Takeda Pharmaceuticals
Verified email at takeda.com
Cited by 109

Understanding sex differences in long-term blood pressure regulation: insights from experimental studies and computational modeling

S Ahmed, R Hu, J Leete… - American Journal of …, 2019 - journals.physiology.org
Sex differences in blood pressure and the prevalence of hypertension are found in humans
and animal models. Moreover, there has been a recent explosion of data concerning sex …

Sex-specific computational models for blood pressure regulation in the rat

S Ahmed, AT Layton - American Journal of Physiology …, 2020 - journals.physiology.org
In the past decades, substantial effort has been devoted to the development of computational
models of the cardiovascular system. Some of these models simulate blood pressure …

Guiding dose selection of monoclonal antibodies using a new parameter (AFTIR) for characterizing ligand binding systems

S Ahmed, M Ellis, H Li, L Pallucchini… - … of pharmacokinetics and …, 2019 - Springer
Guiding the dose selection for monoclonal antibody oncology drugs is often done using
methods for predicting the receptor occupancy of the drug in the tumor. In this manuscript, …

[HTML][HTML] High order integration factor methods for systems with inhomogeneous boundary conditions

S Ahmed, X Liu - Journal of Computational and Applied Mathematics, 2019 - Elsevier
Due to the high order spatial derivatives and stiff reactions, severe temporal stability constraints
on the time step are generally required when developing numerical methods for solving …

[PDF][PDF] Impact of sex and pathophysiology on optimal drug choice in hypertensive rats: quantitative insights for precision medicine

S Ahmed, JC Sullivan, AT Layton - Iscience, 2021 - cell.com
Less than half of all hypertensive patients receiving treatment are successful in normalizing
their blood pressure. Despite the complexity and heterogeneity of hypertension, the current …

[PDF][PDF] Moment stability for nonlinear stochastic growth kinetics of breast cancer stem cells with time-delays

C Guo, CX Guo, S Ahmed, X Liu - Discrete & Continuous …, 2016 - people.math.sc.edu
Solid tumors are heterogeneous in composition. Cancer stem cells (CSCs) are a highly
tumorigenic cell type found in developmentally diverse tumors that are believed to be resistant to …

Stability analysis of mathematical models for nonlinear growth kinetics of breast cancer stem cells

C Guo, S Ahmed, C Guo, X Liu - Mathematical Methods in the …, 2017 - Wiley Online Library
Cancer stem cells are responsible for tumor survival and resurgence and are thus essential
in developing novel therapeutic strategies against cancer. Mathematical models can help …

Sex‐specific Computational Models for Blood Pressure Regulation in the Rat

S Ahmed, J Leete, FL Hernandez… - The FASEB …, 2019 - Wiley Online Library
Renal hemodynamics play a critical role in blood pressure regulation, while renal
autoregulatory mechanisms maintain kidney function for varying blood pressure. Computational …

[HTML][HTML] Integrative Cardiovascular Physiology and Pathophysiology: Understanding sex differences in long-term blood pressure regulation: insights from …

S Ahmed, R Hu, J Leete, AT Layton - American Journal of …, 2019 - ncbi.nlm.nih.gov
Sex differences in blood pressure and the prevalence of hypertension are found in humans
and animal models. Moreover, there has been a recent explosion of data concerning sex …

Is there a cost of virus resistance in marine cyanobacteria?

JT Lennon, SAM Khatana, MF Marston… - The ISME …, 2007 - academic.oup.com
Owing to their abundance and diversity, it is generally perceived that viruses are important
for structuring microbial communities and regulating biogeochemical cycles. The ecological …