[HTML][HTML] Bloom helicase mediates formation of large single–stranded DNA loops during DNA end processing
Bloom syndrome (BS) is associated with a profoundly increased cancer risk and is caused by
mutations in the Bloom helicase (BLM). BLM is involved in the nucleolytic processing of the …
mutations in the Bloom helicase (BLM). BLM is involved in the nucleolytic processing of the …
[HTML][HTML] Cell-free chromatin from dying cancer cells integrate into genomes of bystander healthy cells to induce DNA damage and inflammation
…, K Pal, B Rane, A Shaikh, S Salunkhe… - Cell Death …, 2017 - nature.com
Bystander cells of the tumor microenvironment show evidence of DNA damage and inflammation
that can lead to their oncogenic transformation. Mediator (s) of cell–cell communication …
that can lead to their oncogenic transformation. Mediator (s) of cell–cell communication …
Exploring diffuse radio emission in galaxy clusters and groups with uGMRT and SKA
Diffuse radio emission has been detected in a considerable number of galaxy clusters and
groups, revealing the presence of pervasive cosmic magnetic fields, and of relativistic …
groups, revealing the presence of pervasive cosmic magnetic fields, and of relativistic …
ERBB2 and KRAS alterations mediate response to EGFR inhibitors in early stage gallbladder cancer
…, B Dharavath, R Thorat, S Salunkhe… - … journal of cancer, 2019 - Wiley Online Library
The uncommonness of gallbladder cancer in the developed world has contributed to the
generally poor understanding of the disease. Our integrated analysis of whole exome …
generally poor understanding of the disease. Our integrated analysis of whole exome …
[HTML][HTML] Metabolic rewiring in drug resistant cells exhibit higher OXPHOS and fatty acids as preferred major source to cellular energetics
Alteration in metabolic repertoire is associated with resistance phenotype. Although a common
phenotype, not much efforts have been undertaken to design effective strategies to target …
phenotype, not much efforts have been undertaken to design effective strategies to target …
Inhibition of SETMAR–H3K36me2–NHEJ repair axis in residual disease cells prevents glioblastoma recurrence
…, A Achareker, M Ketkar, D Sarkar, S Salunkhe… - Neuro …, 2020 - academic.oup.com
Background Residual disease of glioblastoma (GBM) causes recurrence. However, targeting
residual cells has failed, due to their inaccessibility and our lack of understanding of their …
residual cells has failed, due to their inaccessibility and our lack of understanding of their …
[HTML][HTML] Up-regulation of the kinase gene SGK1 by progesterone activates the AP-1–NDRG1 axis in both PR-positive and-negative breast cancer cells
…, R Prasad, H Dhamne, K Karve, S Salunkhe… - Journal of Biological …, 2018 - ASBMB
Preoperative progesterone intervention has been shown to confer a survival benefit to breast
cancer patients independently of their progesterone receptor (PR) status. This observation …
cancer patients independently of their progesterone receptor (PR) status. This observation …
Nuclear localization of p65 reverses therapy-induced senescence
Senescence is the arrest of cell proliferation and is a tumor suppressor phenomenon. In a
previous study, we have shown that therapy-induced senescence of glioblastoma multiforme (…
previous study, we have shown that therapy-induced senescence of glioblastoma multiforme (…
Inhibition of novel GCN5–ATM axis restricts the onset of acquired drug resistance in leukemia
S Salunkhe, SV Mishra, J Nair, S Ghosh… - … journal of cancer, 2018 - Wiley Online Library
Leukemia is majorly treated by topoisomerase inhibitors that induce DNA double strand
breaks (DSB) resulting in cell death. Consequently, modulation of DSB repair pathway renders …
breaks (DSB) resulting in cell death. Consequently, modulation of DSB repair pathway renders …
Deciphering the ultra-steep-spectrum diffuse radio sources discovered in the cool-core cluster Abell 980
Clusters of galaxies are excellent laboratories for studying recurring nuclear activity in galactic
nuclei since their hot gaseous medium can vastly prolong the detectability of their radio …
nuclei since their hot gaseous medium can vastly prolong the detectability of their radio …