Cellular senescence suppresses cancer by halting the growth of premalignant cells, yet the
accumulation of senescent cells is thought to drive age-related pathology through a …

Metabolic inflammation in adipose tissue and the liver is frequently observed as a result of
diet-induced obesity in human and rodent studies. Although the adipose tissue and the liver …

Mice deficient in the DNA excision-repair gene Ercc1 (Ercc1 ∆/− ) show numerous accelerated
ageing features that limit their lifespan to 4-6 months 1 , 2 , 3 , 4 . They also exhibit a ‘…

According to the WHO, the proportion of people over 60 years is increasing and expected to
reach 22% of total world’s population in 2050. In parallel, recent animal demographic …

(Fig. 1 a), which is in line with a recent study by Atanasio et al.[1] who report, but do not specify,
decreased survival rates. In line with our previous observations [3], full C9orf72 ablation …

In the late fall of 2004 more severe lesions of porcine circovirus-2 associated disease (PCVAD)
than usual occurred during an outbreak of porcine circovirus-2 (PCV-2) infection in …

Progeroid mouse models display phenotypes in multiple organ systems that suggest premature
aging and resemble features of natural aging of both mice and humans. The prospect of …

The generation of multiciliated cells ( MCC s) is required for the proper function of many
tissues, including the respiratory tract, brain, and germline. Defects in MCC development have …

Background: For clinical translation, we assessed whether intranasal mesenchymal stem cell
(MSC) treatment after hypoxia–ischemia (HI) induces neoplasia in the brain or periphery at …

Background & Aims During liver inflammation, triggering fibrogenesis and carcinogenesis
immune cells play a pivotal role. In the present study we investigated the role of CCL5 in …