Although immune checkpoint blockade therapies have shown evidence of clinical effectiveness
in many types of cancer, the outcome of clinical trials shows that very few patients with …

Understanding the cellular organization of tissues is key to developmental biology. In order
to deal with this complex problem, researchers have taken advantage of reductionist …

Self-organization is an all-important feature of living systems that provides the means to achieve
specialization and functionality at distinct spatio-temporal scales. Herein, we review this …

Tissue elongation is a necessary process in metazoans to implement their body plans that
is not fully understood. Here we propose a mechanism based on the interplay between …

A diverse set of prophage-mediated mechanisms protecting bacterial hosts from infection
has been recently uncovered within cluster N mycobacteriophages isolated on the host, …

Epithelial cell organization and the mechanical stability of tissues are closely related. In this
context, it has been recently shown that packing optimization in bended or folded epithelia is …

Motivation Emerging phenomena in developmental biology and tissue engineering are the
result of feedbacks between gene expression and cell biomechanics. In that context, in silico …

Apico-basal cell intercalations (scutoids) optimize packing and energy expenditure in
curved epithelia. Further consequences of this new paradigm of tissue packing remain …

Within the topic of morphogenesis, tissue elongation is a necessary process in all metazoans
to shape their body plans which is not fully understood. For example, in the particular case …

Building and shaping tissues and organs relies on the ability of epithelial cells to efficiently
pack together. In this context, we recently produced a major breakthrough by showing that …