The removal of functionally dispensable, infected or potentially neoplastic cells is driven by
programmed cell death (PCD) pathways, highlighting their important roles in homeostasis, …

Skin-derived dendritic cells (DCs) include Langerhans cells, classical dermal DCs and a
langerin-positive CD103 + dermal subset. We examined their involvement in the presentation of …

Skin dendritic cells (DCs) are thought to act as key initiators of local T cell immunity. Here
we show that after skin infection with herpes simplex virus (HSV), cytotoxic T lymphocyte (CTL) …

Activated caspases are a hallmark of apoptosis induced by the intrinsic pathway, but they
are dispensable for cell death and the apoptotic clearance of cells in vivo. This has led to the …

Tissue-resident memory T cells provide local immune protection in barrier tissues, such as
skin and mucosa. However, the molecular mechanisms controlling effector T cell retention …

Interactions with the microbiota influence many aspects of immunity, including immune cell
development, differentiation, and function. Here, we examined the impact of the microbiota on …

Humans encode two inflammatory caspases that detect cytoplasmic LPS, caspase‐4 and
caspase‐5. When activated, these trigger pyroptotic cell death and caspase‐1‐dependent IL‐…

Mucosal-associated invariant T cells (MAIT cells) detect microbial vitamin B2 derivatives
presented by the antigen-presenting molecule MR1. Here we defined three developmental …

The immune system can suppress tumour development both by eliminating malignant cells
and by preventing the outgrowth and spread of cancer cells that resist eradication 1 . Clinical …

Adaptive cellular immunity is initiated by antigen-specific interactions between T lymphocytes
and dendritic cells (DCs). Plasmacytoid DCs (pDCs) support antiviral immunity by linking …