BAX is a pro-apoptotic protein of the BCL-2 family that is stationed in the cytosol until activated
by a diversity of stress stimuli to induce cell death. Anti-apoptotic proteins such as BCL-2 …

The historical lack of preclinical models reflecting the genetic heterogeneity of multiple myeloma
(MM) hampers the advance of therapeutic discoveries. To circumvent this limitation, we …

A promising approach to cancer therapy is to elicit apoptosis with “BH3 mimetic” drugs, which
target proteins of the BCL-2 family. As of yet, however, such drugs can target only certain …

The BCL-2 family proteins are major regulators of the apoptosis process, but the
mechanisms by which they regulate this process are only partially understood. It is now well …

B-cell lymphoma 2 (BCL-2) ovarian killer (BOK) is a BCL-2 family protein with high homology
to the multidomain proapoptotic proteins BAX and BAK, yet Bok −/− and even Bax −/− Bok −…

The three-dimensional architecture of the genome affects genomic functions. Multiple genome
architectures at different length scales, including chromatin loops, domains, compartments…

Hydrocarbon stapling is a chemical approach to restoring and fortifying the natural α-helical
structure of peptides that otherwise unfold when taken out of context from the host protein. …

The hematopoietic stem cell (HSC) niche has been extensively studied in bone marrow, yet
a more systematic investigation into the microenvironment regulation of hematopoiesis in …

Calcium transfer from the endoplasmic reticulum (ER) to mitochondria is a critical contributor
to apoptosis. B cell lymphoma 2 (BCL-2) ovarian killer (BOK) localizes to the ER and binds …

The kinesin superfamily of mechanochemical proteins has been implicated in a wide variety
of cellular processes. We have begun studies of kinesins in the unicellular biflagellate alga, …