Many multicellular systems problems can only be understood by studying how cells move,
grow, divide, interact, and die. Tissue-scale dynamics emerge from systems of many …

Motivation: Computational models of multicellular systems require solving systems of PDEs
for release, uptake, decay and diffusion of multiple substrates in 3D, particularly when …

Background Cancer is a complex, multiscale dynamical system, with interactions between
tumor cells and non-cancerous host systems. Therapies act on this combined cancer-host …

Life science researchers use computational models to articulate and test hypotheses about
the behavior of biological systems. Semantic annotation is a critical component for …

Fragile X syndrome (FXS), the most common inherited determinant of intellectual disability
and autism spectrum disorders, is caused by loss of the fragile X mental retardation 1 (FMR1) …

Tumors cannot be understood in isolation from their microenvironment. Tumor and stromal
cells change phenotype based upon biochemical and biophysical inputs from their …

• Cardiopulmonary exercise testing is a noninvasive tool whose clinical value is not yet
widely recognized. The technique involves breath-by-breath measurement of respiratory gas …

Background The increased availability of high-throughput datasets has revealed a need for
reproducible and accessible analyses which can quantitatively relate molecular changes to …

In order to clarify relationships among 4 dimensions thought to underlie schizophrenia, 52
patients were rated on a scale of premorbid personality and on a scale measuring the process-…

Jets from active galactic nuclei (AGNs) in the centers of galaxy clusters inflate cavities of low-density
relativistic plasma and drive shock and sound waves into the intracluster medium. …