Genome-wide association studies (GWASs) for osteoporotic traits have identified over 1000
associations; however, their impact has been limited by the difficulties of causal gene …

Objectives— Chronic hypertension is the most critical risk factor for cardiovascular disease,
heart failure, and stroke. Approach and Results— Here we show that wild-type mice infused …

Recently, IL-12 emerged as a critical player in type 2 diabetes complications. We previously
reported that ischemia-induced angiogenesis is compromised in type 2 diabetic mice. In this …

Relapse in acute myeloid leukemia (AML) patients remains a clinical challenge. The majority
of AML patients who receive induction treatment with combination chemotherapy achieve …

We previously reported that EGFR tyrosine kinase (EGFRtk) activity and endoplasmic reticulum
(ER) stress are enhanced in type 2 diabetic (T2D) mice and cause vascular dysfunction. …

Background Microvascular dysfunction is a major complication in hypertensive patients. We
previously reported that CD4 + CD25 + T regulatory cells (Treg) play an important preventive …

Dear Editor, Acute Myeloid Leukemia (AML) is a heterogeneous hematological malignancy
that most commonly presents in patients over the age of 60 (aged AML or aAML). aAML is …

Gene fusions and their products (RNA and protein) have been traditionally recognized as
unique features of cancer cells and are used as ideal biomarkers and drug targets for multiple …

1. The overall number of genes with recurrent oncogenic and likely oncogenic mutations in
the study cohort was unchanged (Fig. 1A, B, Supplementary Fig. 2). 2. The comparison to …

Objectives: Stromal interacting molecule-1 (STIM1) plays a role in coordinating calcium
signaling in different cell types. The increase or deletion of STIM1 expression in cardiomyocyte …