[PDF][PDF] Human pluripotent stem cell-derived neural cells and brain organoids reveal SARS-CoV-2 neurotropism predominates in choroid plexus epithelium

F Jacob, SR Pather, WK Huang, F Zhang, SZH Wong… - Cell stem cell, 2020 - cell.com
Neurological complications are common in patients with COVID-19. Although severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal pathogen of COVID-19, has …

[PDF][PDF] A patient-derived glioblastoma organoid model and biobank recapitulates inter-and intra-tumoral heterogeneity

…, DY Zhang, PTT Nguyen, JG Schnoll, SZH Wong… - Cell, 2020 - cell.com
Glioblastomas exhibit vast inter- and intra-tumoral heterogeneity, complicating the development
of effective therapeutic strategies. Current in vitro models are limited in preserving the …

[PDF][PDF] Epitranscriptomic m6A regulation of axon regeneration in the adult mammalian nervous system

…, SZH Wong, J Joseph, LC Dore, Q Dong, W Zheng… - Neuron, 2018 - cell.com
N 6 -methyladenosine (m 6 A) affects multiple aspects of mRNA metabolism and regulates
developmental transitions by promoting mRNA decay. Little is known about the role of m 6 A …

[PDF][PDF] Generation of hypothalamic arcuate organoids from human induced pluripotent stem cells

WK Huang, SZH Wong, SR Pather, PTT Nguyen… - Cell stem cell, 2021 - cell.com
Human brain organoids represent remarkable platforms for recapitulating features of human
brain development and diseases. Existing organoid models do not resolve fine brain …

Stem cell competition driven by the Axin2-p53 axis controls brain size during murine development

XL Sun, ZH Chen, X Guo, J Wang, M Ge, SZH Wong… - Developmental Cell, 2023 - cell.com
Cell competition acts as a quality-control mechanism that eliminates cells less fit than their
neighbors to optimize organ development. Whether and how competitive interactions occur …

Hierarchical deployment of Tbx3 dictates the identity of hypothalamic KNDy neurons to control puberty onset

…, L Gao, X Kuang, H Zhang, W Li, SZH Wong… - Science …, 2022 - science.org
The neuroendocrine system consists of a heterogeneous collection of neuropeptidergic neurons
in the brain, among which hypothalamic KNDy neurons represent an indispensable cell …

[PDF][PDF] Decoding neuronal composition and ontogeny of individual hypothalamic nuclei

T Ma, SZH Wong, B Lee, G Ming, H Song - Neuron, 2021 - cell.com
The hypothalamus plays crucial roles in regulating endocrine, autonomic, and behavioral
functions via its diverse nuclei and neuronal subtypes. The developmental mechanisms …

[HTML][HTML] Single-cell RNA sequencing unravels upregulation of immune cell crosstalk in relapsed pediatric ependymoma

…, ZH Chen, J Xu, Y Tian, W Jin, SZH Wong… - Frontiers in …, 2022 - frontiersin.org
Ependymoma (EPN) is a malignant glial tumor occurring throughout central nervous system,
which commonly presents in children. Although recent studies have characterized EPN …

[PDF][PDF] Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism

F Jacob, SR Pather, WK Huang, SZH Wong, H Zhou… - bioRxiv - med.upenn.edu
Neurological complications are common in patients with COVID-19. While SARS-CoV-2, the
causal pathogen of COVID-19, has been detected in some patient brains, its ability to infect …

Single-Cell RNA Sequencing of Pediatric Ependymoma Unravels Subclonal Heterogeneity Associated with Patient Survival

…, Z Liu, Z Chen, J Xu, Y Tian, W Jin, SZH Wong… - bioRxiv, 2022 - biorxiv.org
Ependymoma (EPN) is a malignant glial tumor occurring throughout central nervous system
which commonly presents in children. Although recent studies have characterized EPN …