[PDF][PDF] Human pluripotent stem cell-derived neural cells and brain organoids reveal SARS-CoV-2 neurotropism predominates in choroid plexus epithelium
Neurological complications are common in patients with COVID-19. Although severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal pathogen of COVID-19, has …
respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal pathogen of COVID-19, has …
[PDF][PDF] A patient-derived glioblastoma organoid model and biobank recapitulates inter-and intra-tumoral heterogeneity
Glioblastomas exhibit vast inter- and intra-tumoral heterogeneity, complicating the development
of effective therapeutic strategies. Current in vitro models are limited in preserving the …
of effective therapeutic strategies. Current in vitro models are limited in preserving the …
[PDF][PDF] Epitranscriptomic m6A regulation of axon regeneration in the adult mammalian nervous system
N 6 -methyladenosine (m 6 A) affects multiple aspects of mRNA metabolism and regulates
developmental transitions by promoting mRNA decay. Little is known about the role of m 6 A …
developmental transitions by promoting mRNA decay. Little is known about the role of m 6 A …
[PDF][PDF] Generation of hypothalamic arcuate organoids from human induced pluripotent stem cells
WK Huang, SZH Wong, SR Pather, PTT Nguyen… - Cell stem cell, 2021 - cell.com
Human brain organoids represent remarkable platforms for recapitulating features of human
brain development and diseases. Existing organoid models do not resolve fine brain …
brain development and diseases. Existing organoid models do not resolve fine brain …
Stem cell competition driven by the Axin2-p53 axis controls brain size during murine development
XL Sun, ZH Chen, X Guo, J Wang, M Ge, SZH Wong… - Developmental Cell, 2023 - cell.com
Cell competition acts as a quality-control mechanism that eliminates cells less fit than their
neighbors to optimize organ development. Whether and how competitive interactions occur …
neighbors to optimize organ development. Whether and how competitive interactions occur …
Hierarchical deployment of Tbx3 dictates the identity of hypothalamic KNDy neurons to control puberty onset
…, L Gao, X Kuang, H Zhang, W Li, SZH Wong… - Science …, 2022 - science.org
The neuroendocrine system consists of a heterogeneous collection of neuropeptidergic neurons
in the brain, among which hypothalamic KNDy neurons represent an indispensable cell …
in the brain, among which hypothalamic KNDy neurons represent an indispensable cell …
[PDF][PDF] Decoding neuronal composition and ontogeny of individual hypothalamic nuclei
The hypothalamus plays crucial roles in regulating endocrine, autonomic, and behavioral
functions via its diverse nuclei and neuronal subtypes. The developmental mechanisms …
functions via its diverse nuclei and neuronal subtypes. The developmental mechanisms …
[HTML][HTML] Single-cell RNA sequencing unravels upregulation of immune cell crosstalk in relapsed pediatric ependymoma
…, ZH Chen, J Xu, Y Tian, W Jin, SZH Wong… - Frontiers in …, 2022 - frontiersin.org
Ependymoma (EPN) is a malignant glial tumor occurring throughout central nervous system,
which commonly presents in children. Although recent studies have characterized EPN …
which commonly presents in children. Although recent studies have characterized EPN …
[PDF][PDF] Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism
F Jacob, SR Pather, WK Huang, SZH Wong, H Zhou… - bioRxiv - med.upenn.edu
Neurological complications are common in patients with COVID-19. While SARS-CoV-2, the
causal pathogen of COVID-19, has been detected in some patient brains, its ability to infect …
causal pathogen of COVID-19, has been detected in some patient brains, its ability to infect …
Single-Cell RNA Sequencing of Pediatric Ependymoma Unravels Subclonal Heterogeneity Associated with Patient Survival
…, Z Liu, Z Chen, J Xu, Y Tian, W Jin, SZH Wong… - bioRxiv, 2022 - biorxiv.org
Ependymoma (EPN) is a malignant glial tumor occurring throughout central nervous system
which commonly presents in children. Although recent studies have characterized EPN …
which commonly presents in children. Although recent studies have characterized EPN …