User profiles for Samuele Cazzamalli
 | Samuele CazzamalliPhilochem AG Verified email at philochem.ch Cited by 1091 |
Chemically defined antibody–and small molecule–drug conjugates for in vivo tumor targeting applications: a comparative analysis
S Cazzamalli, A Dal Corso, F Widmayer… - Journal of the American …, 2018 - ACS Publications
We present the first direct comparative evaluation of an antibody–drug conjugate and of a
small molecule–drug conjugate for cancer therapy, using chemically defined products which …
small molecule–drug conjugate for cancer therapy, using chemically defined products which …
An ultra-high-affinity small organic ligand of fibroblast activation protein for tumor-targeting applications
…, F Samain, D Neri, S Cazzamalli - Proceedings of the …, 2021 - National Acad Sciences
We describe the development of OncoFAP, an ultra-high-affinity ligand of fibroblast activation
protein (FAP) for targeting applications with pan-tumoral potential. OncoFAP binds to …
protein (FAP) for targeting applications with pan-tumoral potential. OncoFAP binds to …
Stereo-and regiodefined DNA-encoded chemical libraries enable efficient tumour-targeting applications
…, C Pellegrino, J Millul, R De Luca, S Cazzamalli… - Nature …, 2021 - nature.com
The encoding of chemical compounds with amplifiable DNA tags facilitates the discovery of
small-molecule ligands for proteins. To investigate the impact of stereo- and regiochemistry …
small-molecule ligands for proteins. To investigate the impact of stereo- and regiochemistry …
[HTML][HTML] Translational imaging of the fibroblast activation protein (FAP) using the new ligand [68Ga]Ga-OncoFAP-DOTAGA
…, P Dorten, J Cufe, W Roll, D Neri, S Cazzamalli… - European Journal of …, 2022 - Springer
Purpose The fibroblast activation protein (FAP) is an emerging target for molecular imaging
and therapy in cancer. OncoFAP is a novel small organic ligand for FAP with very high affinity…
and therapy in cancer. OncoFAP is a novel small organic ligand for FAP with very high affinity…
The antibody‐based delivery of interleukin‐12 to solid tumors boosts NK and CD8+ T cell activity and synergizes with immune checkpoint inhibitors
We describe the cloning and characterization of a novel fusion protein (termed L19‐mIL12),
consisting of murine interleukin‐12 in single‐chain format, sequentially fused to the L19 …
consisting of murine interleukin‐12 in single‐chain format, sequentially fused to the L19 …
Versatile protein recognition by the encoded display of multiple chemical elements on a constant macrocyclic scaffold
Y Li, R De Luca, S Cazzamalli, F Pretto, D Bajic… - Nature …, 2018 - nature.com
In nature, specific antibodies can be generated as a result of an adaptive selection and
expansion of lymphocytes with suitable protein binding properties. We attempted to mimic …
expansion of lymphocytes with suitable protein binding properties. We attempted to mimic …
Protease-cleavable linkers modulate the anticancer activity of noninternalizing antibody–drug conjugates
A Dal Corso, S Cazzamalli, R Gébleux… - Bioconjugate …, 2017 - ACS Publications
Antibody–drug conjugates (ADCs) represent an attractive class of biopharmaceutical agents,
with the potential to selectively deliver potent cytotoxic agents to tumors. It is generally …
with the potential to selectively deliver potent cytotoxic agents to tumors. It is generally …
Linker stability influences the anti-tumor activity of acetazolamide-drug conjugates for the therapy of renal cell carcinoma
S Cazzamalli, A Dal Corso, D Neri - Journal of Controlled Release, 2017 - Elsevier
Small molecule-drug conjugates (SMDCs) are increasingly being considered as an alternative
to antibody-drug conjugates (ADCs) for the selective delivery of anticancer agents to the …
to antibody-drug conjugates (ADCs) for the selective delivery of anticancer agents to the …
Enhanced therapeutic activity of non-internalizing small-molecule-drug conjugates targeting carbonic anhydrase IX in combination with targeted interleukin-2
S Cazzamalli, B Ziffels, F Widmayer, P Murer… - Clinical Cancer …, 2018 - AACR
Purpose: Antibody–drug conjugates and small-molecule-drug conjugates have been proposed
as alternatives to conventional anticancer cytotoxic agents, with the potential to deliver …
as alternatives to conventional anticancer cytotoxic agents, with the potential to deliver …
A DNA-encoded chemical library based on chiral 4-amino-proline enables stereospecific isozyme-selective protein recognition
DNA-encoded chemical libraries (DELs) consist of large chemical compound collections
individually linked to DNA barcodes, facilitating pooled construction and screening. However, …
individually linked to DNA barcodes, facilitating pooled construction and screening. However, …